Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
| Autor: | Jørn Bødtker, Trygve Hausken, Steinar Sørnes, Einar K. Kristoffersen, Halvor Naess, Kurt Hanevik, Kristine Mørch, Nina Langeland, Ann Christin Rivenes |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Giardiasis Male medicine.medical_specialty Gastrointestinal Diseases NK cells CD8-Positive T-Lymphocytes medicine.disease_cause Gastroenterology Immunophenotyping lcsh:Infectious and parasitic diseases Functional gastrointestinal disorder Internal medicine medicine Chronic fatigue syndrome Humans Giardia lamblia lcsh:RC109-216 Irritable bowel syndrome Aged Fatigue Syndrome Chronic business.industry NK-cells Chronic fatigue Middle Aged medicine.disease CD8 T-cells Infectious Diseases Gastrointestinal disease Peripheral blood lymphocyte Female business Research Article |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 12, Iss 1, p 258 (2012) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-12-258 |
| Popis: | Background A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting results in CFS and FGID patient populations. The aim of this study was to evaluate a wide selection of markers of immune dysfunction in these two co-occurring post-infectious syndromes. Methods 48 patients, reporting chronic fatigue in a questionnaire study, were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS (n=19) and idiopathic chronic fatigue (n=5) and Rome II criteria for FGIDs (n=54). 22 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Results In peripheral blood we found significantly higher CD8 T-cell levels in PI-FGID, and significantly lower NK-cell levels in PI-CFS patients. Severity of abdominal and fatigue symptoms correlated negatively with NK-cell levels. A tendency towards lower T-cell CD26 expression in FGID was seen. Conclusion Patients with PI-CFS and/or PI-FGID 5 years after Giardia lamblia infection showed alterations in NK-cell and CD8-cell populations suggesting a possible immunological abnormality in these conditions. We found no significant changes in other markers examined in this well-defined group of PI-CFS and PI-FGID elicited by a gastrointestinal infection. Controlling for co-morbid conditions is important in evaluation of CFS-biomarkers. |
| Databáze: | OpenAIRE |
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