Pilot study on the effects of fenfluramine on negative symptoms in twelve schizophrenic inpatients
| Autor: | Stephen M. Stahl, Sarita B. Uhr, Philip A. Berger |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Serotonin Fenfluramine Placebo Placebo group Double-Blind Method Anorexigenic drug Internal medicine Schizophrenic Psychology medicine Humans Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Clinical Trials as Topic Middle Aged medicine.disease Schizophrenia Active treatment Psychology medicine.drug |
| Zdroj: | Biological psychiatry. 20(10) |
| ISSN: | 0006-3223 |
| Popis: | We treated 12 chronic schizophrenic inpatients with fenfluramine, an anorexigenic drug that depletes serotonin, to test the hypothesis that the “negative” symptoms of schizophrenia might be related to brain serotonin activity. We measured change in both positive and negative symptoms in a double-blind, parallel-design trial of fenfluramine or placebo. Negative symptoms improved over time in some individuals within the active treatment group, but not in individuals within the placebo group. However, group comparisons of active treatment versus placebo were not significant. |
| Databáze: | OpenAIRE |
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