High-fat diet prevents eating response and attenuates liver ATP decline in rats given 2,5-anhydro-d -mannitol
| Autor: | Mary Osbakken, Grazyna Graczyk-Milbrandt, James E. Koch, Mark I. Friedman, P. Ulrich |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Food intake Magnetic Resonance Spectroscopy Physiology Energy metabolism Biology Rats Sprague-Dawley Eating chemistry.chemical_compound Adenosine Triphosphate Feeding behavior Physiology (medical) Internal medicine medicine Animals Mannitol Beta oxidation Phosphorus Fructose High fat diet Phosphate Dietary Fats Rats Endocrinology Liver chemistry D-mannitol |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 282:R710-R714 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00156.2001 |
| Popis: | Administration of the fructose analog 2,5-anhydro-d-mannitol (2,5-AM) stimulates eating in rats fed a low-fat diet but not in those fed a high-fat diet that enhances fatty acid oxidation. The eating response to 2,5-AM treatment is apparently triggered by a decrease in liver ATP content. To assess whether feeding a high-fat diet prevents the eating response to 2,5-AM by attenuating the decrease in liver ATP, we examined the effects of the analog on food intake, liver ATP content, and hepatic phosphate metabolism [using in vivo31P-NMR spectroscopy (NMRS)]. Injection (intraperitoneal) of 300 mg/kg 2,5-AM increased food intake in rats fed a high-carbohydrate/low-fat diet, but not in those fed high-fat/low-carbohydrate (HF/LC) food. Liver ATP content decreased in all rats given 2,5-AM compared with saline, but it decreased about half as much in rats fed the HF/LC diet. NMRS on livers of anesthetized rats indicated that feeding the HF/LC diet attenuates the effects of 2,5-AM on liver ATP by reducing phosphate trapping. These results suggest that rats consuming a high-fat diet do not increase food intake after injection of 2,5-AM, because the analog is not sufficiently phosphorylated and therefore fails to decrease liver energy status below a level that generates a signal to eat. |
| Databáze: | OpenAIRE |
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