Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice
| Autor: | Virginie Vasseur, Sabine Charron, Nathalie Van Langendonck, Rachel Guiton, Marbel Torres Arias, Dominique Buzoni-Gatel, Bernhard Ryffel, Isabelle Dimier-Poisson |
|---|---|
| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunologie et Embryologie Moléculaires (IEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Departments of Medicine and Microbiology/Immunology, Dartmouth Medical School, Dartmouth Medical School (DMS), Dartmouth College [Hanover]-Dartmouth College [Hanover] |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
MESH: Signal Transduction MESH: Interleukin-10 MESH: Spleen T-Lymphocytes medicine.medical_treatment MESH: Lymph Nodes Interleukin-17 receptor MESH: Receptors Interleukin-17 MESH: Mice Knockout Mice 0302 clinical medicine Interferon Immunology and Allergy Ileitis MESH: Animals Mice Knockout 0303 health sciences Receptors Interleukin-17 MESH: Toxoplasmosis Animal MESH: Toxoplasma Brain Interleukin Interleukin-10 3. Good health Infectious Diseases Cytokine Liver [SDV.IMM]Life Sciences [q-bio]/Immunology Interleukin 17 medicine.symptom Toxoplasma Signal Transduction medicine.drug MESH: Interferon-gamma Inflammation Biology Interferon-gamma 03 medical and health sciences MESH: Brain Ileum MESH: Mice Inbred C57BL medicine Animals MESH: Mice 030304 developmental biology Toxoplasma gondii biology.organism_classification medicine.disease MESH: Male Mice Inbred C57BL Toxoplasmosis Animal MESH: T-Lymphocytes MESH: Ileum Immunology Lymph Nodes Spleen 030215 immunology MESH: Liver |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (3), pp.427-35. ⟨10.1086/653738⟩ Journal of Infectious Diseases, 2010, 202 (3), pp.427-35. ⟨10.1086/653738⟩ |
| ISSN: | 0022-1899 1537-6613 |
| DOI: | 10.1086/653738⟩ |
| Popis: | International audience; Th17 cells are involved in host defense against several pathogens. Using interleukin (IL) 17RA-deficient mice, we demonstrated reduced ileitis with diminished neutrophil recruitment and inflammatory lesions in the ileum, in the regional lymph node, in the spleen, and in the liver at day 7 and prolonged survival after Toxoplasma gondii infection. In addition, IL-17A antibody neutralization reduced inflammation and enhanced survival in BL6 mice. Diminished inflammation is associated with augmented interferon (IFN) gamma serum levels and enhanced production of IL-10 and IFN-gamma in cultured splenocytes upon antigen restimulation. Finally, cyst load and inflammation in the brain at 40 days are greater in surviving BL6 mice than in IL-17RA-deficient mice. In conclusion, oral T. gondii infection increases IL-17 expression and contributes to the inflammatory response, and IL-17 neutralization has a partial protective effect against fatal T. gondii-associated inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|