Return to the original sport at only 3 months after an Achilles tendon rupture by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and excessively early rehabilitation after operative treatment in a male basketball player: A case report

Autor: Norimasa Nakamura, Hiroshi Nakayama, Shota Morimoto, Toshiya Tachibana, Tetsuo Nishikawa, Kazunori Shimomura, Tomoya Iseki
Rok vydání: 2021
Předmět:
0301 basic medicine
Medicine (General)
medicine.medical_specialty
Basketball
PDGF
Platelet-derived growth factor
MRI
Magnetic resonance imaging
Factor concentrate
VEGF
Vascular endothelial growth factor
Freeze-dried platelet-derived factor concentrate
Biomedical Engineering
Tendon tissue
b-FGF
Basic fibroblastic growth factor
Biomaterials
03 medical and health sciences
R5-920
0302 clinical medicine
Platelet-rich plasma
TGF-β
Transforming growth factor-β
FD-PFC
Freeze-dried platelet-derived factor concentrate
Medicine
Platelet
Early rehabilitation
Achilles tendon rupture
Achilles tendon
Operative treatment
QH573-671
PRP
Plate-rich plasma
business.industry
Platelet-derived growth factor
Return to play
Surgery
030104 developmental biology
medicine.anatomical_structure
Original Article
T2-STIR
T2 weighted short tau inversion recovery
medicine.symptom
Cytology
business
ATRs
Achilles tendon ruptures
IGF
Insulin growth factor
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Regenerative Therapy, Vol 18, Iss, Pp 112-116 (2021)
Regenerative Therapy
ISSN: 2352-3204
DOI: 10.1016/j.reth.2021.05.002
Popis: Background Achilles tendon rupture is one of the most common serious injuries in athletes. Various studies to accelerate the healing process of the Achilles tendon have been performed as it takes a longer time to repair the tissue compared to other tendons. Here, we report a case of an acute Achilles tendon rupture in a male basketball player treated by a combination of an intra-tissue injection of freeze-dried platelet-derived factor concentrate, which included a platelet-derived growth factor with an early rehabilitation protocol after the operative treatment to facilitate the biological healing of the injured tendon tissue. To the best of our knowledge, this case is the first instance that enabled the athlete to return to original sport activity at only 3-months after the injury. Case report A 23-year-old male basketball player who belonged to a university basketball team sustained an Achilles tendon rupture during running in a training match. The remaining time period until the final tournament of the university league as a senior player was only 3 months. The patient received a combination of an intra-tissue injection of freeze-dried platelet-derived factor concentrate and early rehabilitation protocol after operative treatment. Surgery was performed 4 days after the injury and the early rehabilitation protocols were applied postoperatively. A freeze-dried platelet-derived factor concentrate was injected into the ruptured site of the Achilles tendon under ultrasound guide at 4 weeks postoperatively. The patient could return to play at the pre-injury level without any symptoms and disfunctions at 3 months after surgery. At two years postoperatively, the patient could play basketball without symptoms or rerupture. Conclusions We reported a case of an Achilles tendon rupture which was treated by a combination of intra-tissue injection of freeze-dried platelet-derived factor concentrate and an early rehabilitation protocol after the operative treatment. The patient could return to play basketball at the pre-injury activity level at only 3-months after the injury, suggesting that the role of applying excessively early rehabilitation of mechanical loading could facilitate tendon tissue healing when combined with an intra-tissue injection of freeze-dried platelet-derived factor concentrate.
Highlights • FD-PFC has rich growth factors such as PDGF-BB, which is a part of the PDGF growth family. • An achilles tendon rupture was treated by a combination of injection of FD-PFC and excessively postoperative rehabilitation. • The patient could return to play basketball at the pre-injury activity level at only 3-months after the injury.
Databáze: OpenAIRE
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