Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp
| Autor: | Dirk Dressler, Thilo van Eimeren, Susanne A. Schneider, Günther Deuschl, Olav Jansen, Christine Klein, Kirsten E. Zeuner, Julia Götz, Simone Sablowsky, Oliver Granert, Stephan Wolff, Arne Knutzen, Karsten Witt |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cingulate cortex Task specific dystonia Functional magnetic resonance imaging Brodmann area 32 lcsh:RC346-429 Cognition 0302 clinical medicine Reversal learning Probabilistic response Brain Mapping medicine.diagnostic_test Writer's cramp Dopaminergic Brain Regular Article Middle Aged Adaptation Physiological Magnetic Resonance Imaging medicine.anatomical_structure Neurology Dystonic Disorders Basal ganglia lcsh:R858-859.7 Female Psychology psychological phenomena and processes Adult Formative Feedback Genotype Cognitive Neuroscience Posterior parietal cortex Protein Serine-Threonine Kinases lcsh:Computer applications to medicine. Medical informatics Gyrus Cinguli behavioral disciplines and activities Striatum Young Adult 03 medical and health sciences Reward system Reward medicine Humans Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Anterior cingulate cortex Aged DRD2/ANKK1-TaqIa polymorphism Receptors Dopamine D2 medicine.disease 030104 developmental biology Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 10, Iss C, Pp 63-70 (2016) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Previous receptor binding studies suggest dopamine function is altered in the basal ganglia circuitry in task-specific dystonia, a condition characterized by contraction of agonist and antagonist muscles while performing specific tasks. Dopamine plays a role in reward-based learning. Using fMRI, this study compared 31 right-handed writer's cramp patients to 35 controls in reward-based learning of a probabilistic reversal-learning task. All subjects chose between two stimuli and indicated their response with their left or right index finger. One stimulus response was rewarded 80%, the other 20%. After contingencies reversal, the second stimulus response was rewarded in 80%. We further linked the DRD2/ANKK1-TaqIa polymorphism, which is associated with 30% reduction of the striatal dopamine receptor density with reward-based learning and assumed impaired reversal learning in A + subjects. Feedback learning in patients was normal. Blood-oxygen level dependent (BOLD) signal in controls increased with negative feedback in the insula, rostral cingulate cortex, middle frontal gyrus and parietal cortex (pFWE Graphical abstract Highlights • What is the impact of abnormal dopamine signaling on decision making in task specific dystonia? • We studied the neural response in a reinforcement context using fMRI in 31 writer's cramp patients compared to 35 controls. • Patients showed specific increased response after negative feedback in middle ACC (BA 32) • This finding demonstrated disturbed integration of reinforcement history in a task specific dystonia. • The reward system might contribute to the pathogenesis in writer’s cramp |
| Databáze: | OpenAIRE |
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