Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test
| Autor: | Heitor Moreno, Moacir Serralvo Faria, Gilberto De Nucci, Marcelo Nicolas Muscará, Simone A. Teixeira, H. B. Dias, Frederico Guilherme Graeff, Benedito Oliveira |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Mean arterial pressure Elevated plus maze Hypertension Renal Central nervous system Blood Pressure Anxiety Arginine Nitric Oxide Nitric oxide Pathogenesis chemistry.chemical_compound Internal medicine medicine Animals Enzyme Inhibitors Rats Wistar Maze Learning Pharmacology Analysis of Variance Diazepam Nitrates biology business.industry Brain Rats Nitric oxide synthase NG-Nitroarginine Methyl Ester Blood pressure medicine.anatomical_structure Endocrinology Anti-Anxiety Agents chemistry Enzyme inhibitor biology.protein Nitric Oxide Synthase business |
| Zdroj: | European Journal of Pharmacology. 323:37-43 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(97)00027-7 |
| Popis: | The involvement of nitric oxide (NO) in anxiety was investigated in rats, using the elevated plus maze test. Acute, but not chronic, systemic treatment with N omega-nitro-L-arginine methyl ester (L-NAME, 10 and 60 mg.kg-1), an inhibitor of NO synthase, increased the time spent by the rats in the open arms. Both the acute and chronic treatments with L-NAME inhibited NO synthase in endothelial cells and in the central nervous system, as shown by the increase in mean arterial pressure and decreased NO synthase activity in brain tissue. Chronic treatment with L-NAME also decreased the serum nitrate levels. The anxiolysis induced by acute L-NAME treatment is unlikely to be due to hypertension, since two-kidney one-clip hypertension in non-L-NAME-treated rats failed to significantly change exploratory behaviour in the elevated plus maze. These results indicate that acute inhibition of NO synthesis decreases anxiety in rats. |
| Databáze: | OpenAIRE |
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