Computed Tomographic Distinction of Intimal and Medial Calcification in the Intracranial Internal Carotid Artery
| Autor: | Huiberdina L. Koek, Aryan Vink, Wim Van Hecke, Pim A. de Jong, Ronald L. A. W. Bleys, Daphne Verdoorn, Willem P.Th.M. Mali, Annelotte Vos, Jeroen Hendrikse, Remko Kockelkoren, Jill B. De Vis |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Physiology Epidemiology Cerebral arteries lcsh:Medicine Autopsy 030204 cardiovascular system & hematology Vascular Medicine Diagnostic Radiology Cohort Studies 0302 clinical medicine Medicine and Health Sciences lcsh:Science Tomography Aged 80 and over Multidisciplinary Radiology and Imaging Anatomy Arteries Middle Aged Tunica intima Stroke medicine.anatomical_structure Carotid Arteries Neurology Genetic Epidemiology Female Internal carotid artery Tunica Media Carotid Artery Internal Research Article Tunica media Adult Histology Imaging Techniques Cerebrovascular Diseases Neuroimaging Surgical and Invasive Medical Procedures Research and Analysis Methods Calcification Diagnosis Differential 03 medical and health sciences Diagnostic Medicine medicine.artery medicine Journal Article Humans Vascular Calcification Aged business.industry lcsh:R Biology and Life Sciences Reproducibility of Results Cerebral Arteries medicine.disease Internal elastic lamina Computed Axial Tomography Cardiovascular Anatomy Blood Vessels lcsh:Q Differential diagnosis business Physiological Processes Tomography X-Ray Computed Tunica Intima 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 12, Iss 1, p e0168360 (2017) PLoS ONE PLoS ONE [E], 12(1). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Intracranial internal carotid artery (iICA) calcification is associated with stroke and is often seen as a proxy of atherosclerosis of the intima. However, it was recently shown that these calcifications are predominantly located in the tunica media and internal elastic lamina (medial calcification). Intimal and medial calcifications are thought to have a different pathogenesis and clinical consequences and can only be distinguished through ex vivo histological analysis. Therefore, our aim was to develop CT scoring method to distinguish intimal and medial iICA calcification in vivo. METHODS: First, in both iICAs of 16 cerebral autopsy patients the intimal and/or medial calcification area was histologically assessed (142 slides). Brain CT images of these patients were matched to the corresponding histological slides to develop a CT score that determines intimal or medial calcification dominance. Second, performance of the CT score was assessed in these 16 patients. Third, reproducibility was tested in a separate cohort. RESULTS: First, CT features of the score were circularity (absent, dot(s) |
| Databáze: | OpenAIRE |
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