Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery : Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Autor: Marta Bonollo, Andrej Ostapenko, Giacomo Montagna, Francesco Meani, Sander Steffen, Jörg Heil, Michael Bolliger, Paliczek Clara, Elizabeth Morrow, Pristauz-Telsnigg Gunda, Valerijus Ostapenko, Dietmar Heck, Zoltán Mátrai, Andrea S M Alberti, Luca Gambone, Markus Acko, C. André, Daniela Dunkler, Laszlo Romics, Dávid Pukancsik, Katharina Lorenz, Peter Schrenk, Jens-Uwe Blohmer, Florian Fitzal, Fabian Riedel, Edvin Ostapenko, Mathilde Ritter, Arvydas Burneckis, Yves Harder, Ruth Helfgott, Bärbel Papassotiropoulos, E Trapp, Christoph Tausch, Mathias K. Fehr, Régis Resende Paulinelli, Jana de Boniface, Hans-Jörg Fehrer, Angelika Geroldinger, Walter P. Weber
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Annals of surgical oncology, Springer Science and Business Media Deutschland GmbH, 2022, vol. 29, no. 2, p. 1061-1070
Annals of Surgical Oncology
ISSN: 1068-9265
1534-4681
Popis: Introduction Recent data suggest that margins ≥2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tübingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tübingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tübingen 3-4). Methods Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin p < 0.001). There were significantly more re-excisions due to R1 (“ink on tumor”) in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.
Databáze: OpenAIRE
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