Heparin-releasable platelet factor 4 in patients with coronary artery disease
| Autor: | Takao Sadayasu, Yasuhide Nakashima, Takashi Kawashima, Akio Kuroiwa, Akjra Yashiro |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Platelet Aggregation Myocardial Infarction Coronary Disease Platelet Factor 4 Angina Pectoris Coronary artery disease chemistry.chemical_compound Internal medicine medicine Humans Platelet Aged Aged 80 and over Aspirin business.industry General Medicine Heparin Middle Aged medicine.disease beta-Thromboglobulin Pathophysiology Thromboxane B2 Endocrinology chemistry Beta-thromboglobulin Anesthesia Female Cardiology and Cardiovascular Medicine business Platelet factor 4 medicine.drug |
| Zdroj: | Clinical cardiology. 14(9) |
| ISSN: | 0160-9289 |
| Popis: | Recently, platelet factor 4 (PF4) release by heparin (heparin-releasable PF4) has been examined as a useful marker of the interaction between the substances liberated from circulating platelets and the vascular endothelium. We compared the plasma levels of PF4 and β-thromboglobulin (β-TG) after intravenous heparin injection in patients wtih coronary artery disease (CAD) and normal control subjects. We also studied the effects of low-dose aspirin (81 mg/day) on the plasma level of heparin-releasable PF4 in the CAD patients. Blood samples were obtained before and 5 min after the intravenous injection of heparin (1,000 IU) from 23 patients with CAD and 15 normal control subjects. Although the plasma β-TG level remained unchanged after heparin injection, the plasma PF4 level markedly increased in both groups. There was a significant difference in plasma PF4 levels at 5 min after heparin injection between the CAD group (100.1±38.1) and the control group (61.0±;24.0) (p |
| Databáze: | OpenAIRE |
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