Pharmacokinetic based adjustment of lidocaine antiarrhythmic schedule
| Autor: | M. Ionescu, D. D. Ionescu, Mariana Jinga, X. Burcea, G. Lupescu, C. Mircioiu, V. Voicu |
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| Rok vydání: | 1994 |
| Předmět: |
Chromatography
Gas Lidocaine medicine.medical_treatment Myocardial Infarction Multiple dose Injections Intramuscular Sudden death Drug Administration Schedule Pharmacokinetics Oral administration medicine Humans Pharmacology (medical) Myocardial infarction Pharmacology Chemotherapy business.industry Arrhythmias Cardiac Plasma levels medicine.disease Death Sudden Cardiac Delayed-Action Preparations Anesthesia business medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 19:33-36 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | Administration of lidocaine, 200 mg/day i.m. or 275 mg orally, decreased sudden death after myocardial infarct (from 20.7% to 10.3%) although such schedules are not considered adequate to guarantee efficient plasma levels. Inclusion of lidocaine in a polyethylene matrix assured a slow release and complete disappearance of known side effects. Lidocaine was administered 200 mg intramuscularly to hospitalized patients every 6 h or 275 mg oral tablets to healthy volunteers every 8 h and plasma levels evaluated. Plasma levels after oral administration to healthy volunteers showed a great variability, so that it was not possible to draw a statistically significant conclusion about the accumulation of lidocaine in a period of 1 week. In coronary artery disease patients, plasma levels slowly increased with time, but clinical signs indicated, in some cases, a much more rapid accumulation. The therapeutic efficiency at low repeated doses was explained as a consequence of a slow accumulation on the one hand and of the addition of the action of MEGX, the major metabolite of lidocaine, on the other hand. |
| Databáze: | OpenAIRE |
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