Initiating insulin therapy in elderly patients with Type 2 diabetes

Autor: Jessie L. Fahrbach, Sherry Martin, H. Jiang, Bruce H. R. Wolffenbuttel, R. Bhushan, L. J. Klaff
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Blood Glucose
Male
endocrine system diseases
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
insulin analogues
Administration
Oral
Insulin Glargine
Type 2 diabetes
Weight Gain
Gastroenterology
chemistry.chemical_compound
MELLITUS
Endocrinology
Oral administration
GLYCEMIC CONTROL
Insulin
COMPLICATIONS
Insulin Lispro
BLOOD-GLUCOSE
OPEN-LABEL
Insulin
Long-Acting
Treatment Outcome
Drug Therapy
Combination
Female
TRIAL
medicine.symptom
medicine.drug
lispro
medicine.medical_specialty
mix 25
elderly
Drug Administration Schedule
glargine
HYPERGLYCEMIA
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Insulin lispro
COMBINATION
Aged
Glycated Hemoglobin
Dose-Response Relationship
Drug
Insulin glargine
business.industry
PREMIXED INSULIN
medicine.disease
Hypoglycemia
Diabetes Mellitus
Type 2
chemistry
Glycated hemoglobin
business
Weight gain
Zdroj: Diabetic Medicine, 26(11), 1147-1155. Wiley
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2009.02824.x
Popis: AimsTo compare starter insulins in the elderly subgroup of the DURABLE trial 24-week initiation phase.MethodsIn a post-hoc analysis of the >= 65 years subgroup enrolled in the DURABLE trial, we compared the safety and efficacy of lispro mix 25 (LM25: lispro 25%/insulin lispro protamine suspension 75%), n = 258, vs. glargine, n = 222, added to oral glucose-lowering agents.ResultsBaseline glycated hemoglobin (HbA(1c)) was similar (LM25 8.7 +/- 1.2, glargine 8.8 +/- 1.1%, P = 0.612). At 24-weeks, LM25 patients had lower HbA(1c) (7.0 +/- 0.9 vs. 7.3 +/- 0.9%, P ConclusionsIn this elderly subgroup post-hoc analysis, LM25 demonstrated a lower endpoint HbA(1c) and a higher % of patients reaching HbA(1c) target of
Databáze: OpenAIRE
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