Somatic mutation rates scale with lifespan across mammals
| Autor: | Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim H. H. Coorens, Mathijs A. Sanders, Andrew R. J. Lawson, Luke M. R. Harvey, Shriram Bhosle, David Jones, Raul E. Alcantara, Timothy M. Butler, Yvette Hooks, Kirsty Roberts, Elizabeth Anderson, Sharna Lunn, Edmund Flach, Simon Spiro, Inez Januszczak, Ethan Wrigglesworth, Hannah Jenkins, Tilly Dallas, Nic Masters, Matthew W. Perkins, Robert Deaville, Megan Druce, Ruzhica Bogeska, Michael D. Milsom, Björn Neumann, Frank Gorman, Fernando Constantino-Casas, Laura Peachey, Diana Bochynska, Ewan St. John Smith, Moritz Gerstung, Peter J. Campbell, Elizabeth P. Murchison, Michael R. Stratton, Iñigo Martincorena |
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| Přispěvatelé: | Cagan, Alex [0000-0002-7857-4771], Abascal, Federico [0000-0002-6201-1587], Coorens, Tim H. H. [0000-0002-5826-3554], Lawson, Andrew R. J. [0000-0003-3592-1005], Bhosle, Shriram [0000-0002-7638-2899], Jones, David [0000-0002-0407-0386], Butler, Timothy M. [0000-0001-5803-1035], Spiro, Simon [0000-0002-9621-2192], Milsom, Michael D. [0000-0002-3567-254X], Bochynska, Diana [0000-0003-0219-8818], Smith, Ewan St. John [0000-0002-2699-1979], Gerstung, Moritz [0000-0001-6709-963X], Campbell, Peter J. [0000-0002-3921-0510], Murchison, Elizabeth P. [0000-0001-7462-8907], Stratton, Michael R. [0000-0001-6035-153X], Martincorena, Iñigo [0000-0003-1122-4416], Apollo - University of Cambridge Repository, Hematology, Coorens, Tim HH [0000-0002-5826-3554], Lawson, Andrew RJ [0000-0003-3592-1005], Butler, Timothy M [0000-0001-5803-1035], Milsom, Michael D [0000-0002-3567-254X], Smith, Ewan St John [0000-0002-2699-1979], Campbell, Peter J [0000-0002-3921-0510], Murchison, Elizabeth P [0000-0001-7462-8907], Stratton, Michael R [0000-0001-6035-153X], Smith, Ewan [0000-0002-2699-1979], Murchison, Elizabeth [0000-0001-7462-8907] |
| Rok vydání: | 2022 |
| Předmět: |
Scale (anatomy)
Somatic cell Longevity Normal tissue 45/23 631/67/69 Biology 13 14 Oxidative damage Germline mutation Mutation Rate SDG 3 - Good Health and Well-being Animals Humans 631/208/212/748 Mammals Multidisciplinary 45 Mutagenesis 631/443/7 article 45/77 Ageing Evolutionary biology Mutation 631/208/212 14/63 Trait |
| Zdroj: | Nature, 604(7906), 517-524. Nature Publishing Group |
| ISSN: | 0028-0836 |
| Popis: | The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1–7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the evolution of somatic mutation rates and their role in cancer and ageing. Here we performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. We found that somatic mutagenesis was dominated by seemingly endogenous mutational processes in all species, including 5-methylcytosine deamination and oxidative damage. With some differences, mutational signatures in other species resembled those described in humans8, although the relative contribution of each signature varied across species. Notably, the somatic mutation rate per year varied greatly across species and exhibited a strong inverse relationship with species lifespan, with no other life-history trait studied showing a comparable association. Despite widely different life histories among the species we examined—including variation of around 30-fold in lifespan and around 40,000-fold in body mass—the somatic mutation burden at the end of lifespan varied only by a factor of around 3. These data unveil common mutational processes across mammals, and suggest that somatic mutation rates are evolutionarily constrained and may be a contributing factor in ageing. |
| Databáze: | OpenAIRE |
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