A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces
| Autor: | Luis A. Franco, David E. Rivera, Yanet Ocampo, Lia Barrios, Fredyc Diaz, Jenny P. Castro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine medicine.drug_class Physalis angulata 01 natural sciences Article Anti-inflammatory 03 medical and health sciences In vivo medicine Prostaglandin E2 lcsh:QH301-705.5 biology Traditional medicine Macrophages Monocyte Interleukin Nitric oxide biology.organism_classification Folk medicine 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Myeloperoxidase biology.protein Tumor necrosis factor alpha General Agricultural and Biological Sciences 010606 plant biology & botany medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 26, Iss 7, Pp 1758-1766 (2019) |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2018.05.030 |
| Popis: | The use of natural products by communities from the Colombian Caribbean region to treat health issues, together with biodiversity and geographical features, constitute a great scenery to develop new therapies based on ethnopharmacological heritage. Here, we investigated the anti-inflammatory potential of 10 commonly used plants in Colombian folk medicine, evaluating their effect on nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages. The most active plant was evaluated in vivo using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema, along with its effect on the production of pro-inflammatory mediators in vitro. The extract of Physalis angulata L. calyces showed the highest activity. This extract was fractionated and its dichloromethane fraction (DF) was the most active in vitro, inhibiting the production of NO, prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and monocyte chemotactic protein (MCP)-1 (CCL2). In vivo, DF showed a significant inhibition of ear edema and myeloperoxidase (MPO) activity, with evident reduction of the leukocyte infiltration into tissue. Our results support the ethnopharmacological use of the selected plants in folk medicine. P. angulata dichloromethane fraction represents a promising source of pharmacological compounds with great potential therapeutic use to treat inflammatory illness. Keywords: Folk medicine, Anti-inflammatory, Physalis angulata, Nitric oxide, Macrophages |
| Databáze: | OpenAIRE |
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