BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
| Autor: | Daniel R. Soppet, Olga Galperina, Ornella Belvedere, Viktor Roschke, Reiner L. Gentz, David W. Lafleur, Wilbert Greenfield, David Parmelee, David M. Hilbert, Jeffrey Carrell, Ping Feng, Amy Orr, Meghan Charters, Judith Giri, Krystyna Pieri, Svetlana Sosnovtseva, Henrik S. Olsen, James Fikes, Steven M. Ruben, Yuling Li, Bernardetta Nardelli, Paul A. Moore |
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| Rok vydání: | 1999 |
| Předmět: |
Receptor expression
T cell Molecular Sequence Data B-Lymphocyte Subsets Immunoglobulins Biology Lymphocyte Activation Immunoglobulin secretion Atacicept Monocytes Receptors Tumor Necrosis Factor Cell Line Interferon-gamma Mice Species Specificity B-Cell Activating Factor medicine Animals Humans Amino Acid Sequence Receptors Cytokine BAFF receptor B-cell activating factor B cell Cells Cultured B-Lymphocytes Mice Inbred BALB C Multidisciplinary Tumor Necrosis Factor-alpha B-Cell Maturation Antigen Membrane Proteins medicine.disease Recombinant Proteins Up-Regulation medicine.anatomical_structure Immunology Sequence Alignment B-Cell Activation Factor Receptor |
| Zdroj: | Science (New York, N.Y.). 285(5425) |
| ISSN: | 0036-8075 |
| Popis: | The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-γ. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation. |
| Databáze: | OpenAIRE |
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