O'-Methyl derivatives of arabinosylcytosine
| Autor: | J.T. Kuśmierek, Edward Darzynkiewicz, David Shugar |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Aqueous solution
Magnetic Resonance Spectroscopy Chemical Phenomena Stereochemistry Chemistry Antimetabolites Ultraviolet Rays Methanol Biophysics Deamination Cytarabine Cell Biology Sulfuric Acids Chromatography Ion Exchange Biochemistry Methylation carbohydrates (lipids) NMR spectra database Column chromatography Derivative (finance) Spectrophotometry Crystallization Molecular Biology |
| Zdroj: | Biochemical and biophysical research communications. 46(4) |
| ISSN: | 0006-291X |
| Popis: | Dimethylsulphate treatment of 1-β-D-arabinofuranosylcytosine (ara-C) in aqueous alkaline medium, followed by column chromatography, has led to isolation of all possible O'-methylated derivatives of ara-C. The three mono-methylated derivatives were obtained in crystalline form and identified on the basis of NMR spectra and other criteria. The 3′,5′-di-O-methyl derivative was distinguished from the 2′,5′- and 2′,3′- on the basis of its susceptibility to acid-catalyzed deamination. The potential antimetabolic properties of these new ara-C analogues are discussed. |
| Databáze: | OpenAIRE |
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