Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart Disease
| Autor: | Stéphane Zaffran, Heather C. Etchevers, Sonia Stefanovic |
|---|---|
| Přispěvatelé: | Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-09-JCJC-0079,CROCRODIEL,Croissance Cristalline d'Oxydes Dielectriques(2009), ANR-18-CE13-0011,HEARTBOX,HEARTBOX(2018), Gall, Valérie |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Cell type Heart disease [SDV]Life Sciences [q-bio] cardiac progenitor cells [SDV.GEN] Life Sciences [q-bio]/Genetics Review 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine medicine Pharmacology (medical) outflow tract General Pharmacology Toxicology and Pharmaceutics Progenitor cell Endocardium [SDV.GEN]Life Sciences [q-bio]/Genetics business.industry Lateral plate mesoderm Embryogenesis Neural crest second heart field medicine.disease congenital heart defects [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system [SDV] Life Sciences [q-bio] 030104 developmental biology lcsh:RC666-701 Great arteries endocardium Cardiology business valve neural crest 030217 neurology & neurosurgery cushion |
| Zdroj: | Journal of Cardiovascular Development and Disease, Vol 8, Iss 42, p 42 (2021) Journal of Cardiovascular Development and Disease Journal of Cardiovascular Development and Disease, 2021, 8 (4), pp.42. ⟨10.3390/jcdd8040042⟩ Journal of Cardiovascular Development and Disease, MDPI, 2021, 8 (4), pp.42. ⟨10.3390/jcdd8040042⟩ |
| ISSN: | 2308-3425 |
| Popis: | International audience; Anomalies in the cardiac outflow tract (OFT) are among the most frequent congenital heart defects (CHDs). During embryogenesis, the cardiac OFT is a dynamic structure at the arterial pole of the heart. Heart tube elongation occurs by addition of cells from pharyngeal, splanchnic mesoderm to both ends. These progenitor cells, termed the second heart field (SHF), were first identified twenty years ago as essential to the growth of the forming heart tube and major contributors to the OFT. Perturbation of SHF development results in common forms of CHDs, including anomalies of the great arteries. OFT development also depends on paracrine interactions between multiple cell types, including myocardial, endocardial and neural crest lineages. In this publication, dedicated to Professor Andriana Gittenberger-De Groot and her contributions to the field of cardiac development and CHDs, we review some of her pioneering studies of OFT development with particular interest in the diverse origins of the many cell types that contribute to the OFT. We also discuss the clinical implications of selected key findings for our understanding of the etiology of CHDs and particularly OFT malformations. |
| Databáze: | OpenAIRE |
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