Rhodium-catalyzed ortho C-H bond activation of arylamines for the synthesis of quinoline carboxylates
| Autor: | Sunita K. Gadakh, Soumen Dey, Arumugam Sudalai |
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| Rok vydání: | 2016 |
| Předmět: |
Annulation
010405 organic chemistry Formic acid Organic Chemistry Quinoline Regioselectivity chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Enamine Rhodium chemistry.chemical_compound chemistry Amide Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 14(10) |
| ISSN: | 1477-0539 |
| Popis: | The rhodium catalyzed annulation of anilines with alkynic esters allowing for the high-yield synthesis of quinoline carboxylates with excellent regioselectivity is described. This unprecedented reaction employs either formic acid as the C1 source and reductant or copper(II) as the oxidant and is proposed to proceed via rhodacycle of in situ generated amide and enamine ester followed by ortho C–H activation of arylamines with rhodium as the catalyst. |
| Databáze: | OpenAIRE |
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