HTLV-1 infection in solid organ transplant donors and recipients in Spain

Autor: de Mendoza, Carmen, Roc, Lourdes, Benito, Rafael, Reina, Gabriel, Manuel Ramos, Jose, Gomez, Cesar, Aguilera, Antonio, Rodriguez-Iglesias, Manuel, Garcia-Costa, Juan, Fernandez-Alonso, Miriam, Soriano, Vicente, Rodriguez, C., Vera, M., del Romero, J., Marcaida, G., Ocete, M. D., Caballero, E., Molina, I., Rodriguez-Calvino, J. J., Navarro, D., Rivero, C., Vilarino, M. D., Algarate, S., Gil, J., Ortiz de Lejarazu, R., Rojo, S., Eiros, J. M., San Miguel, A., Manzardo, C., Miro, J. M., Garcia, J., Paz, I., Poveda, E., Calderon, E., Escudero, D., Trigo, M., Diz, J., Garcia-Campello, M., Hernandez-Betancor, A., Martin, A. M., Gimeno, A., Gutierrez, F., Rodriguez, J. C., Sanchez, V., Gomez-Hernando, C., Cilla, G., Perez-Trallero, E., Lopez-Aldeguer, J., Fernandez-Pereira, L., Niubo, J., Hernandez, M., Lopez-Lirola, A. M., Gomez-Sirvent, J. L., Force, L., Cifuentes, C., Perez, S., Morano, L., Raya, C., Gonzalez-Praetorius, A., Perez, J. L., Penaranda, M., Hernaez-Crespo, S., Montejo, J. M., Martinez-Sapina, A., Viciana, I., Cabezas, T., Lozano, A., Fernandez, J. M., Garcia-Bermejo, I., Gaspar, G., Garcia, R., Gorgolas, M., Vegas, C., Blas, J., Miralles, P., Valeiro, M., Aldamiz, T., Margall, N., Guardia, C., do Pico, E., Polo, I., Aguinaga, A., Ezpeleta, C., Sauleda, S., Piron, M., Gonzalez, R., Barea, L., Jimenez, A., Blanco, L., Suarez, A., Rodriguez-Avial, I., Perez-Rivilla, A., Parra, P., Fernandez, M., Trevino, A., Requena, S., Benitez-Gu-tierrez, L., Cuervas-Mons, V., Barreiro, P., Soriano, V., Corral, O., Gomez-Gallego, F., Spanish HTLV Network
Přispěvatelé: Bioquímica y Biología Molecular, Microbiología, Medicina Preventiva, Salud Pública, Soriano, Vicente [0000-0002-4624-5199], Soriano, Vicente, [Mendoza C] Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain. Universidad CEU-San Pablo, Madrid, Spain. [Roc L] Hospital Miguel Servet, Zaragoza, Spain. [Benito R] Hospital Lozano Blesa, Zaragoza, Spain. [Reina G] Clínica Universitaria de Navarra, Pamplona, Spain. [Ramos JM] Hospital General Universitario, Alicante, Spain. [Gómez C] Complejo Hospitalario, Toledo, Spain, Vall d'Hebron Barcelona Hospital Campus
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
2420 Virología
medicine.medical_treatment
humanos
Myelopathy
Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies::Retrospective Studies [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
0302 clinical medicine
Medical microbiology
Tropical spastic paraparesis
Infeccions per retrovirus
030212 general & internal medicine
Trasplantació d'òrgans
teixits
etc - Espanya
mediana edad
anciano
Leukemia
Leucèmia
Immunosuppression
adulto
Middle Aged
Tissue Donors
Geographic Locations::Europe::Spain [GEOGRAPHICALS]
Infectious Diseases
trasplante de órganos
virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Deltaretrovirus::infecciones por HTLV-I [ENFERMEDADES]
Cèl·lules T
Screening
Paraparesia espástica tropical
Raonament basat en casos
Ubicaciones Geográficas::Europa (Continente)::España [DENOMINACIONES GEOGRÁFICAS]
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Virus Diseases::RNA Virus Infections::Retroviridae Infections::Deltaretrovirus Infections::HTLV-I Infections [DISEASES]
030106 microbiology
técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes::estudios retrospectivos [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
T cells
Asymptomatic
Health Surveillance of Health Services::Delivery of Health Care::Patient Care::Therapeutics::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Tissue and Organ Harvesting::Organ Transplantation [HEALTH SURVEILLANCE]
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Leucemia de células T adultas
Internal medicine
medicine
VIH (Virus)
Humans
Adult T-cell leukaemia
lcsh:RC109-216
Dialysis
Aged
Retrospective Studies
Transplantation
business.industry
HIV (Viruses)
estudios retrospectivos
donantes de tejidos
Organ Transplantation
medicine.disease
HTLV-I Infections
Spain
HTLV-1
vigilancia sanitaria de los servicios de salud::prestación sanitaria::asistencia al paciente::terapéutica::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::extracción de tejidos y órganos::trasplante de órganos [VIGILANCIA SANITARIA]
Trasplante
HTLV-1 Infection
infecciones por HTLV-I
business
Zdroj: BMC Infectious Diseases (2019) 19:706
BMC Infectious Diseases
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
UVaDOC. Repositorio Documental de la Universidad de Valladolid
BMC INFECTIOUS DISEASES
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Scientia
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
ISSN: 1471-2334
Popis: Consortia on behalf of the Spanish HTLV Network: C. Rodríguez, M. Vera, J. del Romero, G. Marcaida, M. D. Ocete, E. Caballero, I. Molina, A. Aguilera, J. J. Rodríguez-Calviño, D. Navarro, C. Rivero, M. D. Vilariño, R. Benito, S. Algarate, J. Gil, R. Ortiz de Lejarazu, S. Rojo, J. M. Eirós, A. San Miguel, C. Manzardo, J. M. Miró, J. García, I. Paz, E. Poveda, E. Calderón, D. Escudero, M. Trigo, J. Diz, M. García-Campello, M. Rodríguez Iglesias, A. Hernández Betancor, A. M. Martín, J. M. Ramos, A. Gimeno, F. Gutiérrez, J. C. Rodríguez, V. Sánchez, C. Gómez Hernando, G. Cilla, E. Pérez Trallero, J. López Aldeguer, L. Fernández Pereira, J. Niubó, M. Hernández, A. M. López Lirola, J. L. Gómez Sirvent, L. Force, C. Cifuentes, S. Pérez, L. Morano, C. Raya, A. González Praetorius, J. L. Pérez, M. Peñaranda, S. Hernáez Crespo, J. M. Montejo, L. Roc, A. Martínez Sapiña, I. Viciana, T. Cabezas, A. Lozano, J. M. Fernández, I. García-Bermejo, G. Gaspar, R. García, M. Górgolas, C. Vegas, J. Blas, P. Miralles, M. Valeiro, T. Aldamiz, N. Margall, C. Guardia, E. do Pico, I. Polo, A. Aguinaga, C. Ezpeleta, S. Sauleda, M. Pirón, R. González, L. Barea, A. Jiménez, L. Blanco, A. Suárez, I. Rodríguez Avial, A. Pérez Rivilla, P. Parra, M. Fernández, M. Fernández Alonso, A. Treviño, S. Requena, L. Benítez Gutiérrez, V. Cuervas Mons, C. de Mendoza, P. Barreiro, V. Soriano, O. Corral & F. Gómez-Gallego
[Background]: HTLV-1 infection is a neglected disease, despite infecting 10–15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain.
[Methods]: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008.
[Results]: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic.
[Conclusion]: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy.
Databáze: OpenAIRE
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