A translational bridge between mouse and human models of learned safety
| Autor: | Daniela D. Pollak, Ted K. Yanagihara, Joy Hirsch, Tobias Egner, David L. Perez, Michael T. Rogan |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Conditioning Classical Prefrontal Cortex Poison control Neutral stimulus Translational Research Biomedical Mice Avoidance Learning medicine Noxious stimulus Biological neural network Animals Humans medicine.diagnostic_test Classical conditioning Pupil Fear General Medicine Amygdala Magnetic Resonance Imaging Genetic translation Dorsolateral prefrontal cortex Diffusion Tensor Imaging medicine.anatomical_structure Female Functional magnetic resonance imaging Psychology Neuroscience |
| Zdroj: | Annals of Medicine. 42:127-134 |
| ISSN: | 1365-2060 0785-3890 |
| DOI: | 10.3109/07853890903583666 |
| Popis: | Background. Learned safety is established by negatively correlating the occurrence of a neutral stimulus and a noxious stimulus, which renders the previously neutral stimulus a ‘safety signal’. While the neurophysiological and molecular mechanisms have been characterized in mice, it is currently not known how the neural substrates involved compare between mice and people. Methods. Here we attempt to adapt the original animal protocol to humans and use functional magnetic resonance imaging to examine neural responses to the conditioned stimulus in safety conditioned and fear conditioned subjects. Diffusion tensor imaging (DTI) was used in a parallel group of subjects as a fi rst approach to delineate the underlying neural circuitry. Results. Learned safety is associated with dampened amygdala and increased dorsolateral prefrontal cortex and caudate responses and paralleled by pupillary constriction. A neural connection between the amygdala and the dorsolateral prefrontal cortex is suggested by DTI. Conclusion. We present a translational bridge between mouse and human models of learned safety in which cellular and molecular insights from animal experiments are extended to the human neural circuitry. This study provides an example of how animal experiments can be used to inform and target human studies, which in turn can corroborate results obtained in experimental animals. |
| Databáze: | OpenAIRE |
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