Triglyceride–glucose index and the incidence of atherosclerotic cardiovascular diseases: a meta-analysis of cohort studies
| Autor: | Meizi Cui, Manli Zhang, Xiaozhen Wang, Xiaobo Ding, Jing Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Coronary Artery Disease Atherosclerotic cardiovascular diseases Risk Assessment Triglyceride-glucose index Coronary artery disease Insulin resistance Risk Factors Internal medicine Diabetes mellitus Humans Medicine Stroke Triglycerides Aged Original Investigation business.industry Incidence Incidence (epidemiology) Hazard ratio Middle Aged Atherosclerosis medicine.disease Confidence interval Meta-analysis lcsh:RC666-701 Female Cardiology and Cardiovascular Medicine business Biomarkers Cohort study |
| Zdroj: | Cardiovascular Diabetology Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-13 (2021) |
| ISSN: | 1475-2840 |
| DOI: | 10.1186/s12933-021-01268-9 |
| Popis: | Background Insulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride–glucose (TyG) index, a novel surrogate indicator of insulin resistance, and the incidence of ASCVDs in people without ASCVDs at baseline by performing a meta-analysis. Methods Cohort studies reporting the multivariate-adjusted association between the TyG index and the incidence of ASCVDs were obtained by searching the PubMed and Embase databases. A random-effects model incorporating intra-study heterogeneity was applied to combine the results. Results Eight cohort studies comprising 5,731,294 participants were included in this meta-analysis. The results showed that compared to those with the lowest TyG index category, participants with the highest TyG index category were independently associated with a higher risk of ASCVDs [hazard ratio (HR): 1.61, 95% confidence interval (CI) 1.29–2.01, I2 = 80%, P 2 = 89%, P 0.05). Moreover, participants with the highest TyG index category were independently associated with a higher risk of coronary artery disease [(CAD), HR: 1.95, 95% CI 1.47–2.58, I2 = 92%, P 2 = 0%, P Conclusions A higher TyG index may be independently associated with a higher incidence of ASCVDs, CAD, and stroke in people without ASCVDs at baseline. |
| Databáze: | OpenAIRE |
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