5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction
| Autor: | Julián R. Reguero, Eliecer Coto, Mónica García-Castro, Arturo Cortina, Gustavo Iglesias-Cubero, Pelayo González, Blanca Morales, María Martín, Alberto Batalla, Victoria Alvarez |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Serotonin Genotype Population Myocardial Infarction Nerve Tissue Proteins Genetic determinism Gene Frequency Internal medicine Medicine Humans Genetic Predisposition to Disease Receptor Serotonin 5-HT2A Myocardial infarction education Allele frequency Aged First episode Serotonin Plasma Membrane Transport Proteins education.field_of_study Membrane Glycoproteins Polymorphism Genetic business.industry Age Factors Membrane Transport Proteins General Medicine Middle Aged medicine.disease Lipids Genotype frequency Endocrinology Receptors Serotonin Age of onset business Carrier Proteins |
| Zdroj: | Clinical Science. 104:241-245 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs1040241 |
| Popis: | This study was designed to analyse possible associations between DNA polymorphisms in the 5-hydroxytryptamine (5-HT; serotonin) 5-HT2A receptor and the 5-HT transporter (5-HTT) genes, and myocardial infarction (MI). 5-HT has been shown to be involved in cardiovascular pathophysiology. In addition to platelet aggregation and vascular contraction, 5-HT induces hyperplasia of artery smooth muscle cells. Recently, a 5-HT transporter gene polymorphism has been associated with MI. To determine the influence of genetic variation at the 5-HT2A receptor (T102C polymorphism) and the 5-HTT (insertion/deletion polymorphism) on the risk of developing early MI, we genotyped 210 MI patients of 60 years old) to analyse the effects of these polymorphisms on the age at which the first MI episode occurred. The 5-HT2A receptor polymorphism was not associated with MI in our population. In addition, since the 5-HT2A receptor gene and genotype frequencies did not differ between patients with early and late onset of MI, this polymorphism does not appear to have an effect on age at the first MI episode. Gene and genotype frequencies for the 5-HTT promoter did not differ between patients 60 years old compared with patients |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|