Analysis of Micrometastatic Disease in Sentinel Lymph Nodes From Resectable Colon Cancer: Results of Cancer and Leukemia Group B Trial 80001
| Autor: | Mark Redston, Jeannette M. Dowell, Robert J. Mayer, James M. Fleshman, Carolyn C. Compton, Monica M. Bertagnolli, Scott D. Jewell, Brent W. Miedema, Jiri Bem, Donna Niedzwiecki |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Colorectal cancer Sentinel lymph node Isosulfan Blue Predictive Value of Tests Internal medicine Biomarkers Tumor Humans Medicine Neoplasm Staging Sentinel Lymph Node Biopsy business.industry Micrometastasis Cancer medicine.disease Immunohistochemistry Primary tumor Carcinoembryonic Antigen Lymphatic Metastasis Colonic Neoplasms Keratins Histopathology Lymph Nodes Lymph business |
| Zdroj: | Journal of Clinical Oncology. 24:878-883 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2005.03.6038 |
| Popis: | Purpose To determine whether sentinel lymph node (LN) sampling (SLNS) could reduce the number of nodes required to characterize micrometastatic disease (MMD) in patients with potentially curable colon cancer. Patients and Methods Cancer and Leukemia Group B 80001 was a study to determine whether SLNS could identify a subset of LNs that predicted the status of the nodal basin for resectable colon cancer and, therefore, could be extensively evaluated for the presence of micrometastases. Patients enrolled onto this study underwent SLNS after injection of 1% isosulfan blue, and both sentinel nodes (SNs) and non-SNs obtained during primary tumor resection were sectioned at multiple levels and stained using anti–carcinoembryonic antigen and anticytokeratin antibodies. Results Using standard histopathology, SNs failed to predict the presence of nodal disease in 13 (54%) of 24 node-positive patients. Immunostains were performed for patients whose LNs were negative by standard histopathology. Depending on the immunohistochemical criteria used to assign LN positivity, SN examination resulted in either an unacceptably high false-positive rate (20%) or a low sensitivity for detection of MMD (40%). Conclusion By examining both SNs and non-SNs, this multi-institutional study showed that SNs did not accurately predict the presence of either conventionally defined nodal metastases or MMD. As a result, SLNS is not a useful technique for the study of MMD in patients with colon cancer. |
| Databáze: | OpenAIRE |
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