Practical Pd(TFA)2-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via 'One-Pot' Cascade Reactions
| Autor: | Wei Wang, Hao Li, Yang Yu, Wei Yang, Zhiguo Mang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Annulation
Primary (chemistry) 010405 organic chemistry Chemistry one-pot regio-selective Regioselectivity α-alkenyl-dicarbonyl compounds 010402 general chemistry [4+1] annulation lcsh:Chemical technology 01 natural sciences Pd(TFA)2 Catalysis 0104 chemical sciences lcsh:Chemistry unprotected primary amines Cascade reaction lcsh:QD1-999 Organic chemistry lcsh:TP1-1185 tandem reaction Physical and Theoretical Chemistry |
| Zdroj: | Catalysts; Volume 6; Issue 11; Pages: 169 Catalysts, Vol 6, Iss 11, p 169 (2016) |
| ISSN: | 2073-4344 |
| DOI: | 10.3390/catal6110169 |
| Popis: | The Pd(TFA)2-catalyzed [4+1] annulation of chained or cyclic α-alkenyl-dicarbonyl compounds and unprotected primary amines for “one-pot” synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl)methane products. |
| Databáze: | OpenAIRE |
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