Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination
| Autor: | Socrates Konidaris, Dimitrios Hassiakos, Stavroula Baka, K Papadias, Odysseas Grigoriou, Evangelos Makrakis, George Creatsas |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Pregnancy Rate medicine.medical_treatment media_common.quotation_subject Fertility Insemination Obstetrics and gynaecology Pregnancy medicine Humans Prospective Studies Platelet Activating Factor Unexplained infertility media_common Insemination Artificial Homologous Gynecology business.industry Artificial insemination Obstetrics and Gynecology medicine.disease Sperm Spermatozoa Pregnancy rate Treatment Outcome Reproductive Medicine Infertility Female business |
| Zdroj: | Fertility and sterility. 83(3) |
| ISSN: | 0015-0282 |
| Popis: | Objective To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. Design Prospective randomized study. Setting Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. Subject(s) Fifty-two couples with unexplained infertility, candidates for IUI. Intervention(s) Sperm treatment with an exogenous mixture of PAF (final concentration, 10 −7 mol/L) in sperm-washing medium, direct swim-up technique of sperm preparation, a maximum of six IUI cycles per couple with or without PAF treatment. Main outcome measure(s) Clinical pregnancy rate (pregnancies confirmed by ultrasonography per hundred cycles). Result(s) The overall clinical pregnancy rate after a maximum of six IUI cycles was significantly higher when sperm was treated with PAF compared with the rate after the direct swim-up technique (23.07% vs. 7.92%). Conclusion(s) Treatment of sperm with exogenous PAF might improve the clinical outcome of IUI in cases of unexplained infertility. |
| Databáze: | OpenAIRE |
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