A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34
| Autor: | M.T. McDonald, K.A. Papenberg, S. Ghosh, A.A. Glatfelter, B.B. Biesecker, E.A. Helmbold, D.S. Markel, A. Zolotor, W.C. McKinnon, J.L. Vanderstoep, C.E. Jackson, M. Iannuzzi, F.S. Collins, M. Boehnke, M.E. Porteous, A.E. Guttmacher, D.A. Marchuk |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Genetic Markers Male Genetic Linkage Locus (genetics) Telangiectases Biology Gene mapping Genetic linkage Genetics Humans Child Gene Repetitive Sequences Nucleic Acid Polymorphism Genetic Haplotype Chromosome Chromosome Mapping Pedigree Haplotypes Oligodeoxyribonucleotides Genetic marker Female Telangiectasia Hereditary Hemorrhagic Chromosomes Human Pair 9 |
| Zdroj: | Nature genetics. 6(2) |
| ISSN: | 1061-4036 |
| Popis: | Hereditary haemorrhagic telangiectasia (HHT), or Osler-Weber-Rendu disease, is an autosomal dominant vascular dysplasia of unknown pathogenesis leading to 'widespread' dermal, mucosal and visceral telangiectases and recurrent haemorrhage. We have mapped the HHT gene, by linkage analysis, to markers on 9q33-34 in two large multi-generation families. Haplotype analysis and mapping of recombination breakpoints gives a 4 cM interval between D9S61 and D9S63 as the most likely location of the gene. The closest marker, D9S65, is estimated to be within 1 cM of the gene and shows a combined lod score of 11.41. Two potential candidate genes, COL5A1 and ZNF79, are also located within 9q33-34. These results provide a starting point for the eventual cloning of the HHT gene. |
| Databáze: | OpenAIRE |
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