Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

Autor:	Scott E. McNeil, Parag Aggarwal, Marina A. Dobrovolskaia, Jennifer B. Hall, Christopher B. McLeland
Rok vydání:	2009
Předmět:	Drug Carriers Biodistribution Biocompatibility Chemistry Binding protein Pharmaceutical Science Nanoparticle Protein Corona Nanotechnology Blood Proteins Plasma protein binding Article Kinetics Biophysics Animals Humans Nanoparticles Tissue Distribution Microparticle Drug carrier Protein Binding
Zdroj:	Advanced Drug Delivery Reviews. 61:428-437
ISSN:	0169-409X
DOI:	10.1016/j.addr.2009.03.009
Popis:	Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0952d383b493eae8fb7240ec1d81b071 https://doi.org/10.1016/j.addr.2009.03.009 Zobrazit plný text záznamu Full Text from ScienceDirect