Epimeric methylsulfinyladenosine derivatives from the marine ascidian Herdmania momus
| Autor: | Jongki Hong, Haibo Wang, Sook Shin, Eun La Kim, Jian Lin Li, Jee H. Jung, Chong-Kyo Lee |
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| Rok vydání: | 2013 |
| Předmět: |
Adenosine
Magnetic Resonance Spectroscopy Ascidian Stereochemistry Herdmania momus Clinical Biochemistry Pharmaceutical Science Antiviral Agents Biochemistry Article Nucleoside derivatives Drug Discovery Animals Organic chemistry Urochordata Molecular Biology Chromatography High Pressure Liquid ComputingMethodologies_COMPUTERGRAPHICS Molecular Structure biology Chemistry Organic Chemistry Nucleosides Stereoisomerism biology.organism_classification Sulfinyl epimers Viruses Molecular Medicine Epimer Nucleoside |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters |
| ISSN: | 0960-894X |
| Popis: | Graphical abstract Investigation of the secondary metabolites of the ascidian Herdmania momus led to the isolation and characterization of four new nucleoside derivatives (1–4). Structural studies showed that these derivatives represent a series of rare methylsulfinyladenosine derivatives of interconvertible transesterification isomers and/or sulfinyl epimers. The antiviral activities of these rare nucleosides were evaluated against a series of human pathogenic viruses. |
| Databáze: | OpenAIRE |
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