Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers

Autor:	Yu.L. Yagupolskii, Dieter Naumann, Nataliya V. Kirij, Lesya A. Babadzhanova, Wieland Tyrra
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Trifluoromethyl chemistry Trimethylsilyl Trifluoromethylation Organic Chemistry Drug Discovery Tetramethylammonium fluoride Organic chemistry General Medicine Biochemistry Medicinal chemistry Silane
Zdroj:	Tetrahedron. 61:1813-1819
ISSN:	0040-4020
Popis:	A new convenient synthetic procedure to obtain various 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers has been worked out starting from anhydrides or activated esters of carboxylic acids and trimethyl(trifluoromethyl)silane in the presence of tetramethylammonium fluoride. Conditions for the selective formation of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols as well as the trimethylsilyl derivatives have been found.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094fc8da787104f6f8cb05ebebc4278f https://doi.org/10.1016/j.tet.2004.12.023 Zobrazit plný text záznamu Full Text from ScienceDirect