Pharmacokinetics of diphemanil methylsulphate in healthy subjects
| Autor: | Gérard Pons, P. d'Athis, Georges Olive, A. M. Vidal, E. Rey, J. Y. Pello |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pharmacology Drug Metabolic Clearance Rate business.industry media_common.quotation_subject Healthy subjects Administration Oral General Medicine Absorption (skin) Urine Parasympatholytic Bioavailability Piperidines Pharmacokinetics Oral administration Humans Medicine Pharmacology (medical) business media_common |
| Zdroj: | European Journal of Clinical Pharmacology. 42 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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