The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis
| Autor: | Andra H. James, Leo R. Brancazio, Chad A. Grotegut, K. Reddick, Geeta K. Swamy, Michael P. Smrtka |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Randomization medicine.medical_treatment Population Antithrombin III Intermittent pneumatic compression law.invention Young Adult Randomized controlled trial law Pregnancy Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Elective Cesarean Delivery Plasminogen Activator Inhibitor 2 Humans education Intermittent Pneumatic Compression Devices education.field_of_study Obstetrics business.industry Cesarean Section Obstetrics and Gynecology Repeated measures design Urokinase-Type Plasminogen Activator Elective Surgical Procedures Anesthesia Tissue Plasminogen Activator Pediatrics Perinatology and Child Health Female business Plasminogen activator Biomarkers Peptide Hydrolases |
| Zdroj: | American journal of perinatology. 31(9) |
| ISSN: | 1098-8785 |
| Popis: | Objective Pregnancy is associated with increased risk for thromboembolic events. Intermittent pneumatic compression (IPC) devices are the method of thromboprophylaxis in a nonpregnant population. The aim of this study was to examine the effects of IPC on markers of fibrinolysis during cesarean delivery. Study Design We conducted a randomized controlled trial from April 2009 to March 2010 of women undergoing scheduled elective cesarean delivery. Forty-nine women were randomized to IPCs or usual care. All participants had three blood samples obtained: (1) baseline, (2) 1 hour after randomization, and (3) 30 minutes after cesarean delivery. Tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), thrombin-antithrombin complex (TAT), plasminogen activator inhibitor-1 (PAI-1), and plasminogen activator inhibitor-2 (PAI-2) levels were analyzed in each sample using an enzyme-linked immunosorbent assay. Statistical analysis was performed using repeated measures two-way analysis of variance with α = 0.05. Results There was a time-dependent change in tPA, uPA, and PAI-1 levels following delivery but no difference in TAT and PAI-2 levels with time. There were no differences between women randomized to IPCs or usual care. Conclusion Markers of fibrinolysis were not significantly altered by IPCs in this study of low-risk pregnant women. Further research regarding the mechanism and efficacy of IPCs in pregnant women is warranted. |
| Databáze: | OpenAIRE |
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