Serum lipocalin-2 concentrations and mortality of severe traumatic brain injury
| Autor: | Hang-Bin Huang, Chun-Song Yang, Song-Bin Yang, Qing-Wei Lv, Liang-Jun Shen, Qi-Chen Xu, Mi Guo, Jing Zhou |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Traumatic brain injury Clinical Biochemistry Lipocalin Biochemistry Gastroenterology Head trauma 03 medical and health sciences Young Adult 0302 clinical medicine Lipocalin-2 Internal medicine Brain Injuries Traumatic Overall survival medicine Humans Neuroinflammation Aged integumentary system business.industry Biochemistry (medical) Hazard ratio Glasgow Coma Scale General Medicine Odds ratio Middle Aged medicine.disease Surgery 030104 developmental biology ROC Curve Female business 030217 neurology & neurosurgery |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 474 |
| ISSN: | 1873-3492 |
| Popis: | Lipocalin-2 is related to acute brain injury. We assessed the prognostic value of serum lipocalin-2 in head trauma.Blood samples were collected from 115 controls and 115 patients with severe traumatic brain injury. Trauma severity was assessed by Glasgow Coma Scale (GCS) scores at baseline. Thirty-day mortality and overall survival time were recorded.Compared with the controls, serum lipocalin-2 concentrations were significantly increased in the patients. Lipocalin-2 concentrations were independently associated with GCS scores (t=-7.271, P0.001) and serum C-reactive protein concentrations (t=4.325, P0.001). Under receiver operating characteristic curve for 30-day mortality, sensitivity and specificity were 85.7% and 63.2% respectively for lipocalin-2 concentrations at a cutoff value of 591ng/ml. Additionally, area under curve (AUC) of lipocalin-2 concentrations [AUC, 0.825; 95% confidence interval (95% CI), 0.743-0.889] was equivalent to that of GCS scores (AUC, 0.869; 95% CI, 0.793-0.925; P=0.413). Moreover, serum lipocalin-2 concentrations591ng/ml emerged as an independent predictor for 30-day mortality (odds ratio, 4.360; 95% CI, 1.908-12.430) and overall survival (hazard ratio, 3.820; 95% CI, 1.935-10.500).Enhanced serum concentration of lipocalin-2 at admission is associated with trauma severity and neuroinflammation as well as is a predictor of mortality after head trauma. |
| Databáze: | OpenAIRE |
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