| Popis: |
A study was undertaken to investigate subtle bioeffects in Sprague-Dawley rats chronically exposed to a 60-Hz electric field at 80 kV/m unperturbed intensity. The details of our exposure facility, artifact considerations, environmental conditions, and exposure protocol are reported in this paper. Results of electric field exposure on reproduction and prenatal and postnatal development of rats over four generations are discussed. Statistical analysis of data from 305 females, 213 pregnancies, and 2683 births revealed no effects of electric field exposure on fertility, fecundity, nurturing, survival, or sex ratio of off-spring. In the final generation, 51 pregnant females were euthanized between days 16 and 20 of gestation, and 681 fetuses were carefully examined for gross malformations. Statistical analysis indicated that exposure to the electric field produced no significant increase in gross malformations, nor were any differences noted in resorptions, orientation of fetus in utero, sex ratio, or differential frequencies of uterine horn implantation. A detailed discussion of statistical power and sensitivity is included. |
