Molecular Neuroimaging in Posttraumatic Stress Disorder
Autor: | Sujung Yoon, Eun Namgung, Jungyoon Kim, Jooyeon Jamie Im, Yejee Choi, Sandy Jeong Rhie |
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Rok vydání: | 2016 |
Předmět: |
Molecular neuroimaging
Review Article Single-photon emission computed tomography Imaging modalities 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neurochemical Neuroimaging Magnetic resonance spectroscopy (MRS) medicine Prefrontal cortex Single photon emission computed tomography (SPECT) Temporal cortex medicine.diagnostic_test business.industry Posttraumatic stress disorder (PTSD) 030227 psychiatry Posttraumatic stress Positron emission tomography Positron emission tomography (PET) Neurology (clinical) business Nuclear medicine Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Experimental Neurobiology |
ISSN: | 2093-8144 1226-2560 |
DOI: | 10.5607/en.2016.25.6.277 |
Popis: | Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed. |
Databáze: | OpenAIRE |
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