Pharmacokinetic Variability of Aripiprazole and the Active Metabolite Dehydroaripiprazole in Psychiatric Patients
| Autor: | Niclas Lunder, Hilde Lunde, Helge Refsum, Espen Molden |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male CYP2D6 medicine.medical_specialty Adolescent medicine.drug_class Population Aripiprazole Atypical antipsychotic Quinolones Pharmacology Partial agonist Piperazines Pharmacokinetics Cytochrome P-450 CYP2D6 Inhibitors Fluoxetine Internal medicine Humans Medicine Pharmacology (medical) Psychiatry education Active metabolite education.field_of_study medicine.diagnostic_test business.industry Middle Aged Paroxetine Endocrinology Therapeutic drug monitoring Female Drug Monitoring business Antipsychotic Agents medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 28:744-749 |
| ISSN: | 0163-4356 |
| Popis: | Aripiprazole is a new atypical antipsychotic drug with a partial agonist activity at dopamine 2 and serotonin 1A receptors. The metabolism of aripiprazole involves both cytochrome P450 2D6 (CYP2D6) and CYP3A4. This study investigated the pharmacokinetic variability of aripiprazole and the active metabolite dehydroaripiprazole on the basis of 155 drug monitoring samples from psychiatric patients treated with therapeutic doses of aripiprazole (10-30 mg/day). Serum concentrations of drug and metabolite were determined by liquid chromatographic and tandem mass spectrometric detection. Pharmacokinetic variability was expressed as the range in concentration/dose (C/D) ratios, and the effect of sex and occasionally coprescribed CYP2D6 or CYP3A4 inhibitors/inducers was studied. In addition, the dose-concentration relationship and combined interquartile range of concentrations obtained at low dose (10-15 mg/day) and high dose (20-30 mg/day) were described. Individual C/D ratios ranged 37-fold for aripiprazole, 78-fold for dehydroaripiprazole, and 27-fold for the active sum of aripiprazole + dehydroaripiprazole. Median C/D ratios in male and female patients differed by less than 15%, and none of the differences were significant (P > 0.14). Cases of concurrent CYP3A4 inducers/inhibitors were not found, but three patients were coprescribed the potent CYP2D6 inhibitors paroxetine or fluoxetine. No consistent difference in C/D ratio was observed in these three patients compared with the rest of the patients. There was a proportional dose-concentration relationship in the population, and the combined interquartile ranges were 230 to 960 nmol/L for aripiprazole and 330 to 1210 nmol/L for aripiprazole + dehydroaripiprazole. In conclusion, pharmacokinetic variability of aripiprazole is extensive in psychiatric patients but apparently not dependent on dose or sex. The variability of the pharmacologic active sum of aripiprazole + dehydroaripiprazole is 25% to 30% less than aripiprazole, suggesting that variability of aripiprazole is partly determined by metabolism to dehydroaripiprazole. |
| Databáze: | OpenAIRE |
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