Red blood cell omega-3 fatty acids and the risk of ventricular arrhythmias in patients with heart failure
| Autor: | Lutz Klinghammer, Rueth Tobias, Matthias Wilhelm, Robert Kraehner, Simone Kuly, F. Asskali, Hansjosef Boehles, Werner G. Daniel |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Heart disease medicine.medical_treatment Sudden cardiac death Predictive Value of Tests Internal medicine Fatty Acids Omega-3 medicine Humans Heart Failure chemistry.chemical_classification business.industry Fatty acid Arrhythmias Cardiac Middle Aged medicine.disease Implantable cardioverter-defibrillator Fish oil Eicosapentaenoic acid Defibrillators Implantable Endocrinology chemistry Docosahexaenoic acid Case-Control Studies Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 155:971-977 |
| ISSN: | 0002-8703 |
| Popis: | Epidemiological studies support the protective effect of omega-3 fatty acids on sudden cardiac death. However, patients with structural heart disease and an implantable cardioverter defibrillator (ICD) showed no effect or even a proarrhythmic response to fish oil supplementation. Animal studies suggest different electrophysiologic effects of circulating and incorporated omega-3 fatty acids.In 102 ICD patients in New York Health Association functional class II or III, the fatty acid composition of red blood cells was analyzed by gas chromatography. The omega-3 index was calculated from eicosapentaenoic acid and docosahexaenoic acid. Patients were followed for 1 year, and ventricular arrhythmias requiring antitachycardic therapy were analyzed. Twenty-five healthy subjects served as control.In ICD patients, the fatty acid profile was significantly altered and the baseline omega-3 index was significantly elevated, as compared to control subjects (5.12% +/- 0.87% vs 4.24% +/- 0.96%, P.001). Kaplan-Meier estimates of probability of ventricular arrhythmias showed significant differences among quartiles of the omega-3 index. Twelve percent of patients in the lowest quartile had ventricular arrhythmias, as compared to 54% of patients in the highest quartile (P = .022). In a multivariate analysis, the omega-3 index was the only independent predictor for ventricular arrhythmias up to 9 months. At 12 months, a reduced ejection fraction was an additional risk predictor.In heart failure patients, the red blood cell fatty acid profile is altered. Omega-3 fatty acids are elevated and predict the risk of ventricular arrhythmias. |
| Databáze: | OpenAIRE |
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