Low HDL and high triglycerides predict COVID-19 severity
| Autor: | Masana, Luís, Correig, Eudald, Ibarretxe, Daiana, Anoro, Eva, Arroyo-Díaz, Juan Antonio, Jericó, Carlos, Guerrero, Carolina, Miret, Marcel·la, Näf, Silvia, Pardo, Anna, Perea, Verónica, Pérez-Bernalte, Rosa, Plana, Nuria, Ramírez-Montesinos, Rafael, Royuela, Meritxell, Soler, Cristina, Urquizu-Padilla, Maria, Zamora, Alberto, Pedro-Botet, Juan Carlos, The Stacov-Xula Research Group |
|---|---|
| Přispěvatelé: | Institut Català de la Salut, [Masana L, Ibarretxe D] Facultat de Medicina, Universitat Rovira I Virgili, LIPIDCAS, University Hospital Sant Joan, IISPV, CIBERDEM, 43201 Reus, Spain. [Correig E] Statistics Department, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira I Virgili, Reus, Spain. [Anoro E] LIPIDCAS, Pius Hospital Valls, Valls, Spain. [Arroyo JA] Lipid Unit, University Hospital Santa Creu i Sant Pau, Barcelona Autonomous University, Barcelona, Spain. [Jericó C] Lipid Unit, Hospital Moises Broggi, Consorci Sanitari Integral, Sant Joan Despí, Spain. [Urquizu-Padilla M] Unitat de Lípids, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Lípids de la sang Lipids [CHEMICALS AND DRUGS] COVID-19 (Malaltia) - Etiologia 030204 cardiovascular system & hematology Severity of Illness Index Gastroenterology lípidos [COMPUESTOS QUÍMICOS Y DROGAS] chemistry.chemical_compound 0302 clinical medicine virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] técnicas de investigación::métodos epidemiológicos::diseño de la investigación epidemiológica::sensibilidad y especificidad::valor predictivo de las pruebas [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Multidisciplinary biology medicine.diagnostic_test Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] Middle Aged Lipids Hospitalization Medicine Female lipids (amino acids peptides and proteins) medicine.symptom medicine.medical_specialty Prognosi Science Inflammation Article Fibrin Fibrinogen Degradation Products 03 medical and health sciences Internal medicine Severity of illness medicine Other subheadings::Other subheadings::/blood [Other subheadings] Humans Clinical significance Triglycerides Dyslipidaemias Aged Triglyceride Cholesterol business.industry Cholesterol HDL COVID-19 Ferritin 030104 developmental biology chemistry Risk factors Ferritins Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sensitivity and Specificity::Predictive Value of Tests [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Etiology biology.protein Otros calificadores::Otros calificadores::/sangre [Otros calificadores] business Lipid profile |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientific Reports r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Scientia |
| ISSN: | 2045-2322 |
| Popis: | Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Dislipèmies; Factors de risc Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Dislipidemias; Factores de riesgo Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Dyslipidaemias; Risk factors Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19. The work was supported by unrestricted grants from the Institut de Investigació Sanitària Pere Virgili (IISPV) and Xarxa de Unitat de Lipids i Ateriosclerosis (XULA) de Catalunya. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|