Comment on 'DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification'
| Autor: | Gad Getz, Chip Stewart, Julian M. Hess, Ignaty Leshchiner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multidisciplinary Genome Sequence analysis DNA damage Sample processing Confounding High-Throughput Nucleotide Sequencing Computational biology Sequence Analysis DNA Biology Article 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Cancer genome Neoplasms Databases Genetic Mutation Humans Artifacts DNA Software DNA Damage |
| Zdroj: | Science |
| ISSN: | 1095-9203 |
| Popis: | Chen et al . (Reports, 17 February 2017, p. 752) highlight an important problem of sequencing artifacts caused by DNA damage at the time of sample processing. However, their manuscript contains several errors that led the authors to incorrect conclusions. Moreover, the same sequencing artifacts were previously described and mitigated in The Cancer Genome Atlas and other published sequencing projects. |
| Databáze: | OpenAIRE |
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