Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial
Autor: | Z. Shi, Guoxin Li, Wenhua Ling, Honghui Guo, Yanna Zhu, Dan Li, Yan Yang, Fengqiong Liu, T. Zou, F. Song, Yan Zhang, Q. Ye, Zhongxia Li, Yunjun Xiao |
---|---|
Rok vydání: | 2011 |
Předmět: |
Male
medicine.drug_class Endocrinology Diabetes and Metabolism Hypercholesterolemia Interleukin-1beta Anti-Inflammatory Agents Medicine (miscellaneous) Vascular Cell Adhesion Molecule-1 Pharmacology Placebo Anti-inflammatory Proinflammatory cytokine law.invention Anthocyanins chemistry.chemical_compound Randomized controlled trial Double-Blind Method law medicine Humans Nutrition and Dietetics biology Interleukin-6 C-reactive protein Cholesterol HDL food and beverages Cholesterol LDL Hep G2 Cells Middle Aged Atherosclerosis C-Reactive Protein Biochemistry chemistry Cell culture Anthocyanin biology.protein Female Cardiology and Cardiovascular Medicine Cell culture assays |
Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 23(9) |
ISSN: | 1590-3729 |
Popis: | Atherosclerosis is a chronic inflammatory disease and previous studies have demonstrated that anthocyanin inhibits atherosclerosis. In the present study, we explored the effects of anthocyanins on inflammatory cytokines in hypercholesterolemic adults and cell lines.A total of 150 subjects with hypercholesterolemia consumed a purified anthocyanin mixture (320 mg/d) or a placebo twice a day for 24 weeks in a randomized, double-blind trial. Anthocyanin consumption significantly decreased the levels of serum high sensitivity C-reactive protein (hsCRP) (-21.6% vs. -2.5%, P = 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1) (-12.3% vs. 0.4%, P = 0.005) and plasma IL-1β (-12.8% vs. -1.3%, P = 0.019) compared to the placebo. We also found a significant difference in the LDL-cholesterol (-10.4% vs. 0.3%, P = 0.030) and HDL-cholesterol level changes (14.0% vs. -0.9%, P = 0.036) between the two groups. In cell culture assays in vitro, purified anthocyanin mixture, delphinidin-3-Ο-β-glucoside (Dp-3g) and cyanidin-3-Ο-β-glucoside (Cy-3g) inhibited IL-6 and IL-1β-induced CRP production (P0.05) in HepG2 cell line and LPS-induced VCAM-1 secretion (P0.05) in porcine iliac artery endothelial cell line respectively in a dose-dependent manner. In addition, the reduction of inflammatory cytokines associated with anthocyanin mixture was stronger when compared with the effects of Dp-3g and Cy-3g separately (P0.05).Anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects. In addition, different anthocyanin compounds were found to have additive or synergistic effects in mediating anti-inflammatory responses in vitro cell culture assays. |
Databáze: | OpenAIRE |
Externí odkaz: |