Genotoxicity evaluation of magnesium salts of isobutyrate and 2-methylbutyrate
| Autor: | Cristina Marabottini, Paola Ciliutti, Laurie C. Dolan, Laura Bisini, Brian Curtin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Isobutyrate
Magnesium salts 2-methylbutyrate Chemistry Animal feed Health Toxicology and Mutagenesis Regular Article Toxicology medicine.disease_cause Reverse mutation Clastogen Micronucleus In vitro RA1190-1270 Bacterial reverse mutation Toxicology. Poisons medicine Food science Genotoxicity Solubility |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 8, Iss, Pp 1814-1818 (2021) |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2021.10.012 |
| Popis: | Highlights • Magnesium salts of isobutyrate and 2-methylbutyrate are candidates for addition to animal feed. • Both substances were tested for mutagenicity, clastogenicity and aneugenicity in vitro according to OECD Guideline studies. • Neither material was genotoxic. Results of genotoxicity studies for magnesium salts of isobutyrate and 2-methylbutyrate, two candidate ingredients for inclusion in animal feed, are described in this manuscript. Both substances were tested for mutagenicity in a bacterial reverse mutation assay and clastogenicity/aneugenicity in an in vitro micronucleus study in human lymphocytes, conducted according to Organisation for Economic Co-operation and Development (OECD) Guidelines. The substances were tested up to the limits of solubility in the tests. The results showed that that magnesium salts of isobutyrate and 2-methylbutyrate are not mutagenic, clastogenic or aneugenic. The tests were valid, as the negative and positive controls produced expected responses. |
| Databáze: | OpenAIRE |
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