3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu

Autor:	Marija Jovanovic, Petar Uskokovic, Milos Petrovic, Miloš Petrović, Dušica Stojanović
Rok vydání:	2022
Předmět:	Pharmacology microindentation semi-solid extrusion 3D printing in vitro profil i kinetika otpuštanja ibuprofena 3D štampa ekstruzijom iz paste nosač lekova na bazi želatina Pharmaceutical Science mikroindentacija tvrdoća in vitro ibuprofen release and kinetics gelatin-based bone scaffold hardness
Zdroj:	Arhiv za farmaciju Arhiv za Farmaciju Arhiv za farmaciju (2022) 72(6):661-673
ISSN:	2217-8767 0004-1963
Popis:	In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process. Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093effde8c8226bd0bcb0de6353ee70c https://doi.org/10.5937/arhfarm72-40262 Zobrazit plný text záznamu