Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study
| Autor: | Aarti Sahasranaman, Chris Cheyette, Volker Burkart, Jong-Hee Hwang, Konstantinos Kantartzis, Oana P. Zaharia, Julia Szendroedi, Theresa Kössler, Michael I. Trenell, Daniel F. Markgraf, Dominik Pesta, Yanislava Karusheva, Michael Roden, Yuliya Kupriyanova, Kálmán Bódis, Andreas L. Birkenfeld |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (miscellaneous) 030209 endocrinology & metabolism Disease Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Diabetes management Weight loss Internal medicine medicine Humans Life Style Glycemic Nutrition and Dietetics business.industry Fatty liver Original Contribution Insulin sensitivity medicine.disease Fibrosis Digital education Diabetes Mellitus Type 2 Liver Feasibility Studies 030211 gastroenterology & hepatology Insulin Resistance medicine.symptom Transient elastography business Body mass index |
| Zdroj: | European Journal of Nutrition |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-021-02521-3 |
| Popis: | Purpose Recent trials demonstrated remission of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) following formula diet-induced weight loss. To improve the outreach for populations in need, many mobile health apps targeting weight loss have been developed with limited scientific evaluation of these apps. The present feasibility study investigated the effects of a novel approach incorporating a regular ‘whole food-based’ low-calorie diet combined with app-based digital education and behavioral change program on glucose metabolism and disease management. Methods Twenty-four individuals with type 2 diabetes followed this approach supported by weekly coaching calls for 12 weeks. Phenotyping included bioimpedance analysis, mixed-meal tolerance test, magnetic resonance spectroscopy and transient elastography for assessing liver fat content and liver stiffness. Results Over 12 weeks, participants reduced their body weight by 9% (97 ± 13 to 88 ± 12 kg), body mass index (BMI; 33 ± 5 to 29 ± 4 kg/m2), total fat mass (31 ± 10 to 27 ± 10%) (all p Conclusion This novel approach combining digital education with a low-calorie diet results in effective improvements of body weight, glycemic control and NAFLD and could complement existing care for patients with type 2 diabetes. Trial registration NCT04509245 |
| Databáze: | OpenAIRE |
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