Rotavirus Strain Distribution Before and After Introducing Rotavirus Vaccine in India
| Autor: | Nirmal Kumar Mohakud, Venkata Raghava Mohan, Shainey Alokit Khakha, Prasantajyoti Mohanty, Manohar Badur, Rashmi Arora, Sanjeev Chaudhury, Nayana P. Nair, Rajib Kumar Ray, Tintu Varghese, Shayam Kaushik, Mrutunjay Dash, Jacqueline E. Tate, Gagandeep Kang, Chethrapilly Purushothaman Girish Kumar, Seshadri Venkatasubramanian, Umesh D. Parashar, Sidhartha Giri, Geeta Gathwala |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Veterinary medicine rotavirus diarrhea General Immunology and Microbiology business.industry lcsh:R lcsh:Medicine Rotavac vaccine Acute gastroenteritis medicine.disease_cause Group A Rotavirus vaccine Article Diarrhea Infectious Diseases Strain distribution Rotavirus Genotype rotavirus genotyping Immunology and Allergy Medicine Immunization program medicine.symptom business Molecular Biology |
| Zdroj: | Pathogens, Vol 10, Iss 416, p 416 (2021) Pathogens Volume 10 Issue 4 |
| ISSN: | 2076-0817 |
| Popis: | In April 2016, an indigenous monovalent rotavirus vaccine (Rotavac) was introduced to the National Immunization Program in India. Hospital-based surveillance for acute gastroenteritis was conducted in five sentinel sites from 2012 to 2020 to monitor the vaccine impact on various genotypes and the reduction in rotavirus positivity at each site. Stool samples collected from children under 5 years of age hospitalized with diarrhea were tested for group A rotavirus using a commercial enzyme immunoassay, and rotavirus strains were characterized by RT-PCR. The proportion of diarrhea hospitalizations attributable to rotavirus at the five sites declined from a range of 56–29.4% in pre-vaccine years to 34–12% in post-vaccine years. G1P[8] was the predominant strain in the pre-vaccination period, and G3P[8] was the most common in the post-vaccination period. Circulating patterns varied throughout the study period, and increased proportions of mixed genotypes were detected in the post-vaccination phase. Continuous long-term surveillance is essential to understand the diversity and immuno-epidemiological effects of rotavirus vaccination. |
| Databáze: | OpenAIRE |
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