Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort
| Autor: | Teepen, J.C., Kremer, L.C., Heiden-van der Loo, M. van der, Tissing, W.J., Pal, H.J. van der, Heuvel-Eibrink, M.M. van den, Loonen, J.J., Louwerens, M., Versluys, B., Dulmen-den Broeder, E. van, Visser, O., Maduro, J.H., Leeuwen, F.E. van, Ronckers, C.M., Bresters, D., Batenburg, L., Veening, M., Huizinga, G., Steeg, L. van der, Jaspers, M., Vries, A. de, Aleman, B.M.P., Caron, H.N., Grootenhuis, M.A., Hartogh, J.G. den, Hollema, N., Neggers, S.J.C.M.M., Postma, A., Ridder-Sluiter, J.G. de, Rutgers, E.J.T., DCOG-LATER Study Grp |
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| Přispěvatelé: | Graduate School, CCA - Cancer Treatment and Quality of Life, ARD - Amsterdam Reproduction and Development, Paediatric Oncology, Child and Adolescent Psychiatry & Psychosocial Care, APH - Mental Health, APH - Methodology, Epidemiology and Data Science, Amsterdam Reproduction & Development (AR&D), Pediatric surgery, CCA - Cancer Treatment and quality of life, Pediatrics, Internal Medicine, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male Cancer Research Skin Neoplasms PROGNOSIS Survival Epidemiology medicine.medical_treatment Childhood cancer survivors Cohort Studies SOFT-TISSUE SARCOMAS 0302 clinical medicine Cancer Survivors Neoplasms Medicine 030212 general & internal medicine Sarcoma/epidemiology Child 2ND PRIMARY Melanoma Netherlands RISK education.field_of_study Breast Neoplasms/epidemiology Hazard ratio Neoplasms Second Primary Sarcoma 030220 oncology & carcinogenesis HEALTH OUTCOMES Skin Neoplasms/epidemiology Female Adult medicine.medical_specialty Population Long-term complications Second Primary/epidemiology Breast Neoplasms Melanoma/epidemiology Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences Breast cancer All institutes and research themes of the Radboud University Medical Center SDG 3 - Good Health and Well-being Internal medicine PRIMARY THYROID-CANCER Journal Article Humans education business.industry Proportional hazards model HODGKINS-LYMPHOMA Cancer LONG-TERM SURVIVAL 5-YEAR SURVIVORS medicine.disease Survival Analysis Cancer registry Subsequent malignant neoplasm Radiation therapy RADIATION Neoplasms Second Primary/epidemiology business |
| Zdroj: | Cancer causes & control. Springer Netherlands Cancer Causes & Control, 30, 9, pp. 909-922 Cancer Causes and Control, 30(9), 909. Springer Netherlands Cancer Causes and Control, 30(9), 909-922. Springer Netherlands Cancer Causes & Control, 30(9), 909-922. Springer Netherlands Cancer Causes & Control, 30, 909-922 Teepen, J C, Kremer, L C, van der Heiden-van der Loo, M, Tissing, W J, van der Pal, H J, van den Heuvel-Eibrink, M M, Loonen, J J, Louwerens, M, Versluys, B, van Dulmen-den Broeder, E, Visser, O, Maduro, J H, van Leeuwen, F E, Ronckers, C M & the DCOG-LATER Study Group 2019, ' Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort ', Cancer Causes and Control, vol. 30, no. 9, pp. 909-922 . https://doi.org/10.1007/s10552-019-01204-z Cancer causes & control, 30(9), 909-922. SPRINGER Cancer Causes and Control, 30(9), 909-922. SPRINGER |
| ISSN: | 1573-7225 0957-5243 |
| DOI: | 10.1007/s10552-019-01204-z |
| Popis: | PURPOSE: Childhood cancer survivors are at increased risk of developing subsequent malignant neoplasms (SMNs). We compared survival and clinical characteristics of survivors with SMNs (sarcoma, breast cancer, or melanoma) and a population-based sample of similar first malignant neoplasm (FMN) patients.METHODS: We assembled three case series of solid SMNs observed in a cohort of 5-year Dutch childhood cancer survivors diagnosed 1963-2001 and followed until 2014: sarcoma (n = 45), female breast cancer (n = 41), and melanoma (n = 17). Each SMN patient was sex-, age-, and calendar year-matched to 10 FMN patients in the population-based Netherlands Cancer Registry. We compared clinical and histopathological characteristics by Fisher's exact tests and survival by multivariable Cox regression and competing risk regression analyses.RESULTS: Among sarcoma-SMN patients, overall survival [hazard ratio (HR) 1.88, 95% confidence interval (CI) 1.23-2.87] and sarcoma-specific mortality (HR 1.91, 95% CI 1.16-3.13) were significantly worse compared to sarcoma-FMN patients (foremost for soft-tissue sarcoma), with 15-year survival rates of 30.8% and 61.6%, respectively. Overall survival did not significantly differ for breast-SMN versus breast-FMN patients (HR 1.14, 95% CI 0.54-2.37), nor for melanoma-SMN versus melanoma-FMN patients (HR 0.71, 95% CI 0.10-5.00). No significant differences in tumor characteristics were observed between breast-SMN and breast-FMN patients. Breast-SMN patients were treated more often with mastectomy without radiotherapy/chemotherapy compared to breast-FMN patients (17.1% vs. 5.6%).CONCLUSIONS: Survival of sarcoma-SMN patients is worse than sarcoma-FMN patients. Although survival and tumor characteristics appear similar for breast-SMN and breast-FMN patients, treatment differs; breast-SMN patients less often receive breast-conserving therapy. Larger studies are necessary to substantiate these exploratory findings. |
| Databáze: | OpenAIRE |
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