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Kuzminskyi I. V., Krylyuk V. O., Maksymenko M. A. Bile production features in case of ischemic-reperfusion syndrome of limbs, abdominal trauma complicated with massive blood loss. Journal of Education, Health and Sport. 2018;8(10):209-218. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1473020 http://ojs.ukw.edu.pl/index.php/johs/article/view/6234 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.10.2018. Revised: 19.10.2018. Accepted: 22.10.2018. UDC 612.357.6-02:616.711/616-001.3]-092.9 BILE PRODUCTION FEATURES IN CASE OF ISCHEMIC-REPERFUSION SYNDROME OF LIMBS, ABDOMINAL TRAUMA COMPLICATED WITH MASSIVE BLOOD LOSS I. V. Kuzminskyi, V. O. Krylyuk, M. A. Maksymenko GO "Ukrainian Scientific and Practical Center of Emergency and Disaster Medicine Ministry of Health of Ukraine", Kyiv, Ukraine Abstract The level of total bile acids in bile decreased in the groups of experimental animals in comparison with the control group. In the group of animals with simulated ischemic-reperfusion injury level of total bile acids in bile reached the minimal values in on the 3rd day, increasing was showed after on the 7th day, however level still remained lower than in control group. In EG-2 and EG-3 there was a unidirectional decreasing of the index by the seventh day, but in EG-3 these changes were more significant. Consequently, the level of cholesterol in the bile due to simulated injuries decreased in EG-1 and reached the minimal values in on the 3rd day and slightly increased to the seventh day of observation. In EG-2 the index gradually increased to the seventh day of observation. In EG-3 the maximum increasing was observed until the third day, after which it was at the same level. The analysis of the obtained indices testifies to the negative influence of ischemic-reperfusion syndrome on the level of cholesterol in the bile. Described changes influenced the cholato-cholesterol ratio, which was decreasing in all experimental groups. The most significant changes were in EG-3 in which abdominal trauma and hypovolemic shock were combined with ischemic-reperfusion limb syndrome. In the conditions of an experimental trauma with an ischemic-reperfusion injury of the lower limbs, there is a violation of the indices of the biliary function of the liver, which manifest themselves as a significant reduction of the level of total bile acids in the bile with increasing cholesterol concentration. Keywords: biliary production, trauma, bleeding, reperfusion syndrome, experiment. |
