Olive Oil and Vitamin D Synergistically Prevent Bone Loss in Mice
| Autor: | Véronique Coxam, Sylvie Mercier, Marie-Jeanne Davicco, Stéphane Walrand, Stéphane Georgé, Marie-Jo Amiot, Yohann Wittrant, Alain Huertas, Camille Tagliaferri, Patrice Lebecque, Amélie Dhaussy |
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| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Lesieur, Biochemistry Department, Centre Technique de la Conservation des Produits Agricole, Site Agroparc (CTCPA), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Conventions Industrielles de Formation par la REcherche grant (CIFRE) grant from the French National Association for Research and Technology [2011/99], CIFRE, pOLIVd3 ANR (French National Research Agency) [ANR-10-ALIA-0008], Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), HAL AMU, Administrateur |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Mediterranean diet
Bone density Physiology Osteoclasts lcsh:Medicine MACROPHAGE ACTIVATION souris Diet Mediterranean medicine.disease_cause marqueur Bone remodeling Mice chemistry.chemical_compound Bone Density Medicine and Health Sciences Vitamin D Reproductive System Procedures OXIDATIVE STRESS lcsh:Science Bone Demineralization Pathologic Immune Response Connective Tissue Cells 2. Zero hunger Bone mineral [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology Multidisciplinary Bone Density Conservation Agents ANTIOXIDANT SYSTEM Drug Synergism densité minérale régime méditerranéen OVARIECTOMY/INFLAMMATION EXPERIMENTAL-MODEL PHENOLIC-COMPOUNDS MEDITERRANEAN DIET métabolisme osseux Connective Tissue Body Composition Ovariectomized rat Female Anatomy Menopause Research Article Vitamin medicine.medical_specialty Ovariectomy Immunology Surgical and Invasive Medical Procedures rat ovariectomise Bone and Bones ostéoporose polyphénol Dietary Fats Unsaturated huile d'olive vierge Internal medicine OVARIECTOMIZED MICE medicine Animals Plant Oils Bone Olive Oil Nutrition Inflammation Osteoblasts NITRIC-OXIDE Endocrine Physiology Surgical Excision lcsh:R Polyphenols Biology and Life Sciences stress oxydatif Estrogens Nutrients Mice Inbred C57BL Biological Tissue Endocrinology chemistry densité osseuse lcsh:Q MINERAL DENSITY INFLAMMATION-INDUCED OSTEOPOROSIS Oxidative stress [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (e115817), ⟨10.1371/journal.pone.0115817⟩ PLoS ONE, 2014, 9 (e115817), e115817 (19 p.). ⟨10.1371/journal.pone.0115817⟩ Plos One 12 (9), e115817 (19 p.). (2014) PLoS ONE, Vol 9, Iss 12, p e115817 (2014) PLoS ONE, Public Library of Science, 2014, 9 (e115817), e115817 (19 p.). ⟨10.1371/journal.pone.0115817⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; As the Mediterranean diet (and particularly olive oil) has been associated with bone health, we investigated the impact of extra virgin oil as a source of polyphenols on bone metabolism. In that purpose sham-operated (SH) or ovariectomized (OVX) mice were subjected to refined or virgin olive oil. Two supplementary OVX groups were given either refined or virgin olive oil fortified with vitamin D3, to assess the possible synergistic effects with another liposoluble nutrient. After 30 days of exposure, bone mineral density and gene expression were evaluated. Consistent with previous data, ovariectomy was associated with increased bone turnover and led to impaired bone mass and micro-architecture. The expression of oxidative stress markers were enhanced as well. Virgin olive oil fortified with vitamin D3 prevented such changes in terms of both bone remodeling and bone mineral density. The expression of inflammation and oxidative stress mRNA was also lower in this group. Overall, our data suggest a protective impact of virgin olive oil as a source of polyphenols in addition to vitamin D3 on bone metabolism through improvement of oxidative stress and inflammation. |
| Databáze: | OpenAIRE |
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