Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice

Autor:	Anna E. King, Jessica M Collins, James C. Vickers, Adele Woodhouse, Matthew T. K. Kirkcaldie
Rok vydání:	2019
Předmět:	Oncology 030506 rehabilitation medicine.medical_specialty Aging Traumatic brain injury Diffuse Axonal Injury Mice Transgenic Plaque Amyloid Disease 03 medical and health sciences Amyloid beta-Protein Precursor Mice 0302 clinical medicine Alzheimer Disease Internal medicine Brain Injuries Traumatic medicine Presenilin-1 Animals Risk factor Beta (finance) business.industry medicine.disease Mice Inbred C57BL Disease Models Animal Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery
Zdroj:	Journal of neurotrauma. 36(11)
ISSN:	1557-9042
Popis:	Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have examined the effect of TBI on subsequent beta-amyloid (Aβ) deposition in APP/PS1 (APP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093778feaa27217b4d9ec9b9998af661 https://pubmed.ncbi.nlm.nih.gov/30623730 Zobrazit plný text záznamu