Physical activity, high-density lipoprotein cholesterol subfractions and lecithin:cholesterol acyltransferase in dialysis patients
| Autor: | Hideki Hirakata, Keiko Miyahara, Keiko Mizuuchi, Hiroyuki Imamura, Harumitsu Kumagai, Reika Masuda |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Very low-density lipoprotein Low-density lipoprotein receptor-related protein 8 Heart disease Motor Activity chemistry.chemical_compound High-density lipoprotein Renal Dialysis Internal medicine Lecithins medicine Humans Risk factor business.industry Cholesterol Reverse cholesterol transport nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Endocrinology chemistry Nephrology Kidney Failure Chronic lipids (amino acids peptides and proteins) Female Phosphatidylcholine—sterol O-acyltransferase business Lipoproteins HDL Sterol O-Acyltransferase |
| Zdroj: | Nephron. Clinical practice. 111(4) |
| ISSN: | 1660-2110 |
| Popis: | Background/Aims: Although a low level of high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for atherosclerotic heart disease, the mechanism of HDL-C abnormality in hemodialysis (HD) as well as peritoneal dialysis (PD) patients is not fully understood. The purpose of this study was to investigate the relationship of physical activity with HDL-C subfractions and lecithin:cholesterol acyltransferase activity in HD and PD patients. Methods: Thirty-five HD and 26 PD patients were studied. Physical activity was estimated as the average number of steps taken per day over 7 days (steps/day). Results: When possible confounding factors were included in the stepwise multiple regression analyses, in HD patients, steps/day was significantly positively related to HDL2-C and apolipoprotein (Apo) A-I, while it was significantly positively related to HDL3-C in PD patients. When subjects were subdivided into 3 groups according to steps/day, in HD patients, the highest category of steps/day had significantly higher HDL2-C and Apo A-I than the lowest category, while such results were not observed in PD patients. Conclusion: These results suggest that the associations of physical activity with HDL-C subfractions and Apo A-I that are known in the general population are more pronounced in HD patients than PD patients. |
| Databáze: | OpenAIRE |
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