Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units for High Relaxivity Performance in MRI
| Autor: | Graeme J. Stasiuk, Anthony E. G. Cass, Nicolas G. Chabloz, Il Chul Yoon, James D. E. T. Wilton-Ely, Daniel S. Elson, Hannah L. Perry, Margot N. Wenzel, Susannah Molisso |
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| Přispěvatelé: | Imperial College/Wellcome Trust Facility Network of Excellence scheme |
| Rok vydání: | 2019 |
| Předmět: |
dithiocarbamates
Biocompatibility FUNCTIONALIZED GOLD NANOPARTICLES Chemistry Multidisciplinary Gadolinium RESONANCE-IMAGING CONTRAST chemistry.chemical_element Nanoparticle QUANTUM DOTS 010402 general chemistry 01 natural sciences Catalysis PEG ratio MULTIMETALLIC COMPLEXES AGENTS Dithiocarbamate SILICA NANOPARTICLES FOLATE RECEPTOR PHOTOTHERMAL THERAPY STEPWISE GENERATION chemistry.chemical_classification Science & Technology 010405 organic chemistry Organic Chemistry imaging General Chemistry Photothermal therapy Combinatorial chemistry 0104 chemical sciences Chemistry chemistry Folate receptor Colloidal gold gold nanoparticles Physical Sciences DITHIOCARBAMATE LIGANDS gadolinium 03 Chemical Sciences MRI |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 25(46) |
| ISSN: | 1521-3765 |
| Popis: | The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r1) from 4.0 mM‐1 s‐1 in unbound form to 34.3 mM‐1 s‐1 (at 10 MHz, 37 °C) and 22 ± 2 mM‐1s‐1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The ‘one‐pot’ synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units improving biocompatibility (PEG and thioglucose units) and targeting (folic acid) lead to little detrimental effect on the high relaxivity observed for these non‐toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies. |
| Databáze: | OpenAIRE |
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