Parenteral Nutrition and Cardiotoxicity
| Autor: | Vidul Murali, Ashish Samaddar, Eric Song, Joseph Krebs, Chandrashekhara Manithody, Austin Armstrong, Ajay Jain, Marcus Voigt, Johan van Nispen, Margarita Fedorova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Heart Injury Parenteral Nutrition Heart Diseases 030204 cardiovascular system & hematology Toxicology Antioxidants Receptors G-Protein-Coupled 03 medical and health sciences Liver disease 0302 clinical medicine medicine Animals Humans Animal study Medical nutrition therapy Intensive care medicine Adverse effect Molecular Biology Organ system Cardiotoxicity business.industry medicine.disease Biopterin Oxidative Stress Parenteral nutrition 030220 oncology & carcinogenesis Cardiology and Cardiovascular Medicine business Reactive Oxygen Species Signal Transduction |
| Zdroj: | Cardiovascular toxicology. 21(4) |
| ISSN: | 1559-0259 |
| Popis: | Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances. |
| Databáze: | OpenAIRE |
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